Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 134
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 112
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 94
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 89
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 84
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 83
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
LEP P41159 leptin 0.46 0.349 0.846 78
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 71
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 67
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
HLA-DQB1 P01920 major histocompatibility complex, class II, DQ beta 1 Immune response 8.9E-03 0.407 0.885 53
CCR5 P51681 C-C motif chemokine receptor 5 (gene/pseudogene) G-protein coupled receptor 4.3E-10 0.398 0.885 49
ADM P35318 adrenomedullin Signaling 4.1E-02 0.436 0.808 43
HLA-B P01889 major histocompatibility complex, class I, B 3.9E-05 0.379 0.885 41
SLC6A4 P31645 solute carrier family 6 member 4 Transporter 0.25 0.429 0.808 41
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 39
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 34
LEPR P48357 leptin receptor Signaling 0.99 0.433 0.808 33