Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
FLNA P21333 filamin A 1.00 0.456 0.793 361
KRAS P01116 KRAS proto-oncogene, GTPase enzyme modulator 9.0E-04 0.350 0.724 341
COL2A1 P02458 collagen type II alpha 1 chain 1.00 0.474 0.724 312
FGFR3 P22607 fibroblast growth factor receptor 3 1.8E-05 0.417 0.759 312
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase 1.00 0.352 0.793 303
FBN1 P35555 fibrillin 1 calcium-binding protein; cell adhesion molecule; extracellular matrix protein; signaling molecule 1.00 0.469 0.690 266
PTEN P60484 phosphatase and tensin homolog hydrolase; phosphatase 0.82 0.334 0.828 243
EP300 Q09472 E1A binding protein p300 nucleic acid binding; transcription factor; transferase 1.00 0.489 0.828 209
NRAS P01111 NRAS proto-oncogene, GTPase enzyme modulator 0.53 0.420 0.690 206
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinase; transferase 1.00 0.341 0.897 199
PRKAR1A P10644 protein kinase cAMP-dependent type I regulatory subunit alpha 1.00 0.466 0.690 199
MED12 Q93074 mediator complex subunit 12 nucleic acid binding; transcription factor 1.00 0.528 0.655 192
CREBBP Q92793 CREB binding protein nucleic acid binding; transcription factor; transferase 1.00 0.451 0.862 189
RECQL4 O94761 RecQ like helicase 4 nucleic acid binding 5.1E-33 0.524 0.759 183
MECP2 P51608 methyl-CpG binding protein 2 nucleic acid binding; transferase 0.78 0.463 0.862 182
FLNB O75369 filamin B 4.9E-10 0.501 0.862 179
TRPV4 Q9HBA0 transient receptor potential cation channel subfamily V member 4 transporter 2.6E-16 0.519 0.759 176
PIEZO2 Q9H5I5 piezo type mechanosensitive ion channel component 2 2.3E-06 0.573 0.655 173
AKT1 P31749 AKT serine/threonine kinase 1 calcium-binding protein; kinase; transfer/carrier protein; transferase 0.98 0.355 0.862 172
PTPN11 Q06124 protein tyrosine phosphatase, non-receptor type 11 1.00 0.429 0.828 168
KAT6B Q8WYB5 lysine acetyltransferase 6B nucleic acid binding; transcription factor; transferase 1.00 0.565 0.690 164
FKRP Q9H9S5 fukutin related protein 6.3E-05 0.514 0.586 162
NSD1 Q96L73 nuclear receptor binding SET domain protein 1 1.00 0.546 0.655 162
RAI1 Q7Z5J4 retinoic acid induced 1 transcription factor 1.00 0.558 0.621 162