Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 101
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 72
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 71
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 62
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 49
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 48
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
PPARGC1A Q9UBK2 PPARG coactivator 1 alpha Transcription factor 1.00 0.453 0.885 42
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 42
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 41
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 37
LEP P41159 leptin 0.46 0.349 0.846 34
AGT P01019 angiotensinogen Enzyme modulator 5.0E-08 0.367 0.923 32
G6PD P11413 glucose-6-phosphate dehydrogenase Enzyme 0.97 0.424 0.846 32
HP P00738 haptoglobin Enzyme 1.7E-05 0.412 0.885 30
IGF2 P01344 insulin like growth factor 2 4.4E-02 0.390 0.885 28
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 23
VCAM1 P19320 vascular cell adhesion molecule 1 0.80 0.422 0.808 21
CD36 P16671 CD36 molecule Receptor 1.1E-60 0.446 0.846 20
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692 18
KL Q9UEF7 klotho Enzyme 2.2E-04 0.448 0.769 17
LPL P06858 lipoprotein lipase Enzyme 1.3E-09 0.474 0.808 17