Source: ANIMAL_MODELS

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 138
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 58
IFNG P01579 interferon gamma 0.47 0.288 0.962 36
BAD Q92934 BCL2 associated agonist of cell death 4.6E-03 0.553 0.769 30
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 30
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 28
ANGPT2 O15123 angiopoietin 2 Signaling 0.83 0.410 0.846 25
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 23
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 22
CTSB P07858 cathepsin B Enzyme 5.9E-11 0.457 0.846 22
F2 P00734 coagulation factor II, thrombin Enzyme 1.1E-03 0.415 0.885 21
BDKRB2 P30411 bradykinin receptor B2 G-protein coupled receptor 0.12 0.585 0.808 17
EPOR P19235 erythropoietin receptor Receptor 1.0E-02 0.526 0.692 17
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 17
LGALS3 P17931 galectin 3 Signaling 2.3E-05 0.392 0.846 15
AKT2 P31751 AKT serine/threonine kinase 2 Kinase 0.64 0.474 0.769 14
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731 13
ATG7 O95352 autophagy related 7 Enzyme 7.4E-12 0.505 0.769 11
CXCR3 P49682 C-X-C motif chemokine receptor 3 G-protein coupled receptor 0.18 0.436 0.808 10
HRAS P01112 HRas proto-oncogene, GTPase Enzyme modulator 8.0E-02 0.378 0.885 10
MKI67 P46013 marker of proliferation Ki-67 1.3E-28 0.431 0.808 10
SLC6A3 Q01959 solute carrier family 6 member 3 Transporter 1.00 0.453 0.885 10
TNC P24821 tenascin C 1.3E-07 0.433 0.846 10
CSF1 P09603 colony stimulating factor 1 1.00 0.473 0.808 8