| BRAF |
P15056
|
B-Raf proto-oncogene, serine/threonine kinase
|
Kinase
|
1.00 |
0.319 |
0.846 |
125
|
84 |
| PTEN |
P60484
|
phosphatase and tensin homolog
|
Enzyme
|
0.26 |
0.305 |
0.923 |
107
|
343 |
| MTOR |
P42345
|
mechanistic target of rapamycin kinase
|
Kinase
|
1.00 |
0.343 |
0.885 |
86
|
26 |
| PIK3CA |
P42336
|
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
|
Kinase
|
1.00 |
0.292 |
0.923 |
85
|
55 |
| TP53 |
P04637
|
tumor protein p53
|
Transcription factor
|
0.53 |
0.236 |
0.962 |
84
|
390 |
| FGFR2 |
P21802
|
fibroblast growth factor receptor 2
|
Kinase
|
1.00 |
0.380 |
0.808 |
82
|
76 |
| HRAS |
P01112
|
HRas proto-oncogene, GTPase
|
Enzyme modulator
|
8.0E-02 |
0.378 |
0.885 |
71
|
21 |
| BRCA2 |
P51587
|
BRCA2 DNA repair associated
|
Nucleic acid binding
|
2.4E-25 |
0.379 |
0.846 |
68
|
2953 |
| GNAS |
O95467 P63092 P84996 Q5JWF2
|
GNAS complex locus
|
Enzyme modulator
|
0.68 |
0.420 |
0.885 |
60
|
27 |
| PALB2 |
Q86YC2
|
partner and localizer of BRCA2
|
|
3.0E-19 |
0.485 |
0.769 |
48
|
393 |
| CHEK2 |
O96017
|
checkpoint kinase 2
|
Kinase
|
1.2E-24 |
0.460 |
0.808 |
48
|
209 |
| ATM |
Q13315
|
ATM serine/threonine kinase
|
Kinase
|
5.6E-47 |
0.374 |
0.885 |
44
|
888 |
| C11orf65 |
Q8NCR3
|
chromosome 11 open reading frame 65
|
|
2.0E-14 |
0.670 |
0.462 |
32
|
342 |
| PPP2R1A |
P30153
|
protein phosphatase 2 scaffold subunit Aalpha
|
Enzyme
|
0.98 |
0.588 |
0.577 |
26
|
6 |
| MED12 |
Q93074
|
mediator complex subunit 12
|
Transcription factor
|
1.00 |
0.476 |
0.769 |
25
|
18 |
| ERBB2 |
P04626
|
erb-b2 receptor tyrosine kinase 2
|
Kinase
|
6.0E-03 |
0.328 |
0.923 |
23
|
28 |
| BRCA1 |
P38398
|
BRCA1 DNA repair associated
|
Enzyme
|
9.2E-29 |
0.367 |
0.923 |
22
|
2439 |
| FBXW7 |
Q969H0
|
F-box and WD repeat domain containing 7
|
Enzyme modulator
|
1.00 |
0.465 |
0.808 |
18
|
7 |
| IDH1 |
O75874
|
isocitrate dehydrogenase (NADP(+)) 1
|
|
2.6E-12 |
0.424 |
0.808 |
18
|
2 |
| SMAD4 |
Q13485
|
SMAD family member 4
|
Transcription factor
|
1.00 |
0.401 |
0.808 |
16
|
133 |
| BRIP1 |
Q9BX63
|
BRCA1 interacting protein C-terminal helicase 1
|
Enzyme
|
6.2E-17 |
0.507 |
0.731 |
15
|
220 |
| ERBB3 |
P21860
|
erb-b2 receptor tyrosine kinase 3
|
Kinase
|
1.7E-15 |
0.448 |
0.808 |
12
|
7 |
| HERC2 |
O95714
|
HECT and RLD domain containing E3 ubiquitin protein ligase 2
|
|
1.00 |
0.568 |
0.692 |
11
|
9 |
| POLE |
Q07864
|
DNA polymerase epsilon, catalytic subunit
|
|
8.0E-27 |
0.526 |
0.731 |
10
|
9 |