Source: LHGDN

Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 351
Gene Symbol: APP
APP
amyloid beta precursor protein 0.430 0.862 6.2E-02
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.900 0.967 81 0 1987 2018
Entrez Id: 348
Gene Symbol: APOE
APOE
apolipoprotein E 0.352 0.931 1.7E-03
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.700 0.922 61 0 1991 2018
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
presenilin 1 0.490 0.690 0.98
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.700 0.939 49 0 1990 2018
Entrez Id: 6653
Gene Symbol: SORL1
SORL1
sortilin related receptor 1 0.619 0.483 1.1E-09
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.700 0.986 11 0 2004 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
angiotensin I converting enzyme 0.367 0.897 1.6E-37
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.600 0.859 8 0 1998 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
interleukin 1 beta 0.312 0.931 0.13
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.600 0.946 5 0 1989 2017
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
glycogen synthase kinase 3 beta 0.488 0.793 0.96
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.600 0.919 4 0 2000 2016
Entrez Id: 627
Gene Symbol: BDNF
BDNF
brain derived neurotrophic factor 0.382 0.828 0.70
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.600 0.976 2 0 1992 2018
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
plasminogen activator, urokinase 0.434 0.690 2.1E-06
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.580 1.000 4 0 1994 2014
Entrez Id: 3630
Gene Symbol: INS
INS
insulin 0.458 0.828 0.32
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.520 1.000 1 0 1991 2007
Entrez Id: 5664
Gene Symbol: PSEN2
PSEN2
presenilin 2 0.567 0.517 2.4E-03
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.500 0.978 10 0 1995 2018
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
triggering receptor expressed on myeloid cells 2 0.572 0.552 4.0E-09
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.500 0.963 1 0 2007 2018
Entrez Id: 1191
Gene Symbol: CLU
CLU
clusterin 0.456 0.793 5.7E-05
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.500 0.963 1 0 1991 2018
Entrez Id: 7447
Gene Symbol: VSNL1
VSNL1
visinin like 1 0.652 0.345 0.49
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.450 1.000 1 0 2002 2016
Entrez Id: 27328
Gene Symbol: PCDH11X
PCDH11X
protocadherin 11 X-linked 0.720 0.345 1.9E-02
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.420 1.000 1 0 2009 2011
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
microtubule associated protein tau 0.492 0.724 7.3E-03
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.979 35 0 1988 2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
beta-secretase 1 0.616 0.517 0.88
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.952 25 0 1999 2018
Entrez Id: 590
Gene Symbol: BCHE
BCHE
butyrylcholinesterase 0.503 0.793 1.1E-12
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.944 7 0 1995 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
tumor necrosis factor 0.263 0.966 0.80
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.896 6 0 1999 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
estrogen receptor 1 0.355 0.897 1.00
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 1.000 5 0 1999 2016
Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
cholinergic receptor nicotinic alpha 7 subunit 0.550 0.552 1.5E-03
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 1.000 5 0 2001 2015
Entrez Id: 2
Gene Symbol: A2M
A2M
alpha-2-macroglobulin 0.564 0.724 5.6E-11
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.848 4 0 1998 2016
Entrez Id: 1718
Gene Symbol: DHCR24
DHCR24
24-dehydrocholesterol reductase 0.572 0.655 3.8E-02
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.950 3 0 2001 2016
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
vascular endothelial growth factor A 0.298 0.897 2.7E-05
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.950 3 0 2005 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
interleukin 6 0.287 0.966 0.34
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
disease 0.400 0.929 3 0 1993 2017