Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD

Entrez Id: 727
Gene Symbol: C5
C5
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. 11591795

2001

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation. 12604708

2003

Entrez Id: 7356
Gene Symbol: SCGB1A1
SCGB1A1
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD [Expression of Clara cell secretory protein in airways of rat asthma remodel]. 12921604

2003

Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
CUI: C0004096
Disease: Asthma
Asthma
0.220 Biomarker RGD Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation. 15245576

2004

Entrez Id: 624
Gene Symbol: BDKRB2
BDKRB2
CUI: C0004096
Disease: Asthma
Asthma
0.200 Biomarker RGD Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. 14727005

2004

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Tissue inhibitor-1 of metalloproteinases is a specific inhibitor of MMP-9; the MMP-9 and TIMP-1 imbalance could lead to airway inflammation and remodeling in lung disease such as asthma. 16191269

2005

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Therapeutic RGD STAT6 protein and STAT6 mRNA were found strongly expressed in rat asthma model and the epithelial cells were the chief expressing cells. 16083555

2005

Entrez Id: 6361
Gene Symbol: CCL17
CCL17
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD In contrast to the findings in the asthma and lung fibrosis models, the increased expression of MDC and TARC in the cigarette-smoke model was not associated with an increased infiltration of Th2 cells into smoke-treated lungs. 15993846

2005

Entrez Id: 1233
Gene Symbol: CCR4
CCR4
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker RGD Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. 15993846

2005

Entrez Id: 4048
Gene Symbol: LTA4H
LTA4H
CUI: C0004096
Disease: Asthma
Asthma
0.280 Biomarker RGD The expression of 5-LO and LTA4-H mRNA, and 5-LO protein levels were increased in lung tissue and cerebral cortex in asthma rats. 15715933

2005

Entrez Id: 6367
Gene Symbol: CCL22
CCL22
CUI: C0004096
Disease: Asthma
Asthma
0.270 Biomarker RGD In contrast to the findings in the asthma and lung fibrosis models, the increased expression of MDC and TARC in the cigarette-smoke model was not associated with an increased infiltration of Th2 cells into smoke-treated lungs. 15993846

2005

Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD LIF and NK-1R were excessively expressed and closely correlated in lungs of the rat asthmatic model, suggesting that LIF may be involved in modulating airway neurogenic inflammation. 16409782

2005

Entrez Id: 5321
Gene Symbol: PLA2G4A
PLA2G4A
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD This study demonstrates, for the first time in vivo, a negative feedback between sPLA2 and cPLA2 and assigns opposing roles for these enzymes in asthma pathophysiology: sPLA2 activation induces production of the bronchoconstrictor CysLT and suppresses cPLA2 expression and the subsequent production of the bronchodilator PGE2. 15557087

2005

Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
CUI: C0004096
Disease: Asthma
Asthma
0.220 Biomarker RGD NGF can upregulate the expressions of p75 and trkA mRNA in asthmatic rats, and then may promote their role in the airway neuronal inflammation in asthma. 16708804

2005

Entrez Id: 653509
Gene Symbol: SFTPA1
SFTPA1
CUI: C0004096
Disease: Asthma
Asthma
0.220 Biomarker RGD Decrease of the surface fraction of surfactant proteins containing clara cells and type II pneumocytes in a rat asthma model. 15816355

2005

Entrez Id: 6439
Gene Symbol: SFTPB
SFTPB
CUI: C0004096
Disease: Asthma
Asthma
0.210 Biomarker RGD Decrease of the surface fraction of surfactant proteins containing clara cells and type II pneumocytes in a rat asthma model. 15816355

2005

Entrez Id: 1237
Gene Symbol: CCR8
CCR8
CUI: C0004096
Disease: Asthma
Asthma
0.210 Biomarker RGD Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. 15993846

2005

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models]. 17074272

2006

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker RGD [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models]. 17074272

2006

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule. 16540403

2006

Entrez Id: 1232
Gene Symbol: CCR3
CCR3
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker RGD Topical inhibition of CCR3 expression, using an AS-ODN, could represent a novel approach for the treatment of asthma. 16978084

2006

Entrez Id: 355
Gene Symbol: FAS
FAS
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. 16337971

2006

Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0004096
Disease: Asthma
Asthma
0.230 Biomarker RGD In summary, bronchial epithelial cell changes in asthma are induced by LIF which promotes the expression of NK-1R, and JAK/STAT pathway and MAPK/ERK pathway may participate in this process. 17392578

2006

Entrez Id: 4282
Gene Symbol: MIF
MIF
CUI: C0004096
Disease: Asthma
Asthma
0.220 Biomarker RGD The results indicate that macrophage migration inhibitory factor plays a crucial role in airway inflammation and airway hyperresponsiveness in asthma. 16455830

2006