Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Biomarker RGD The combination of 31409163

2020
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0001306
Disease: Acute alcoholic liver disease
Acute alcoholic liver disease 		0.200 Therapeutic RGD Optimal ratio of 18α- and 18β-glycyrrhizic acid for preventing alcoholic hepatitis in rats. 31258651

2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0002103
Disease: Atopic rhinitis
Atopic rhinitis 		0.200 Therapeutic RGD [Acupoint application of herbal paste relieves symptoms and naso-mucosal inflammatory response by down-regulating serum TGF-β1 in allergic rhinitis rats]. 31368266

2019
Entrez Id: 196500
Gene Symbol: PIANP
PIANP
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.200 Biomarker MGD Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior. 31511635

2019
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Therapeutic RGD Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. 30148677

2019
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
CUI: C0009207
Disease: Cockayne Syndrome
Cockayne Syndrome 		0.200 Biomarker MGD New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653

2019
Entrez Id: 9211
Gene Symbol: LGI1
LGI1
CUI: C0014549
Disease: Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsy 		0.200 Therapeutic RGD Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats. 30813600

2019
Entrez Id: 3643
Gene Symbol: INSR
INSR
CUI: C0015696
Disease: Fatty Liver, Alcoholic
Fatty Liver, Alcoholic 		0.200 Therapeutic RGD Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity. 30642871

2019
Entrez Id: 407015
Gene Symbol: MIR26A1
MIR26A1
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.200 Biomarker CTD_rat A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats. 30682439

2019
Entrez Id: 55486
Gene Symbol: PARL
PARL
CUI: C0023264
Disease: Leigh Disease
Leigh Disease 		0.200 Biomarker MGD PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. 30578322

2019
Entrez Id: 406953
Gene Symbol: MIR18A
MIR18A
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.200 ModifyingMutation RGD A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. 30191950

2019
Entrez Id: 407014
Gene Symbol: MIR25
MIR25
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.200 ModifyingMutation RGD A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. 30191950

2019
Entrez Id: 406957
Gene Symbol: MIR181C
MIR181C
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.200 Biomarker RGD MicroRNA‑181c suppresses growth and metastasis of hepatocellular carcinoma by modulating NCAPG. 31114379

2019
Entrez Id: 406900
Gene Symbol: MIR106B
MIR106B
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.200 ModifyingMutation RGD MicroRNA-106b-5p promotes hepatocellular carcinoma development via modulating FOG2. 31406464

2019
Entrez Id: 1241
Gene Symbol: LTB4R
LTB4R
CUI: C0027719
Disease: Nephrosclerosis
Nephrosclerosis 		0.200 Biomarker CTD_mouse Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. 30818366

2019
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Biomarker RGD The expression and activity of phase I enzymes (CYP1A2, CYP2B1, CYP2C11, CYP3A1, CYP4A1 and FMO1) and phase II enzymes (UGT1A1, UGT1A3, UGT1A6, UGT1A9, UGT2B7, NAT1 and GSTT1) were decreased in the liver of obese rats. 31063713

2019
Entrez Id: 128178
Gene Symbol: EDARADD
EDARADD
CUI: C0029882
Disease: Otitis Media
Otitis Media 		0.200 Biomarker RGD Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. 31028034

2019
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.200 Biomarker MGD New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653

2019
Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.200 Biomarker RGD Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na 31250553

2019
Entrez Id: 24145
Gene Symbol: PANX1
PANX1
CUI: C0085548
Disease: Autosomal Recessive Polycystic Kidney Disease
Autosomal Recessive Polycystic Kidney Disease 		0.200 Biomarker RGD Knockout of 31630543

2019
Entrez Id: 90956
Gene Symbol: ADCK2
ADCK2
CUI: C0162670
Disease: Mitochondrial Myopathies
Mitochondrial Myopathies 		0.200 Biomarker MGD ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. 31480808

2019
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
CUI: C0175691
Disease: Dubowitz syndrome
Dubowitz syndrome 		0.200 Biomarker MGD New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653

2019
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.200 Biomarker MGD New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653

2019
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653

2019
Entrez Id: 407014
Gene Symbol: MIR25
MIR25
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.200 ModifyingMutation RGD A novel SOCS5/miR-18/miR-25 axis promotes tumorigenesis in liver cancer. 30191950

2019