Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome
0.510 Biomarker RGD The serum alpha 2M concentration was increased approximately equal to 50-fold and was proportional to synthesis (r = 0.91 P < 0.001). alpha 2-Macroglobulin synthesis increased by 12-fold in NAR and 50-fold in NS. 9453001

1998

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.510 Biomarker RGD Distinctive immunohistochemical staining for alpha(2)M could be consistently demonstrated in GST-P-negative HAF, HCA, and HCC induced not only by peroxisome proliferators but also N-nitrosodiethylamine alone. 15509519

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0206669
Disease: Hepatocellular Adenoma
Hepatocellular Adenoma
0.500 Biomarker RGD Distinctive immunohistochemical staining for alpha(2)M could be consistently demonstrated in GST-P-negative HAF, HCA, and HCC induced not only by peroxisome proliferators but also N-nitrosodiethylamine alone. 15509519

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0239981
Disease: Hypoalbuminemia
Hypoalbuminemia
0.210 Biomarker RGD Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms. 9453001

1998

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0243026
Disease: Sepsis
Sepsis
0.210 Biomarker RGD Isolation of bona fide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization. 15167684

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0243026
Disease: Sepsis
Sepsis
0.210 Biomarker RGD Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat. 9843780

1998

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.200 Biomarker RGD Cancer-related anemia in a rat model: alpha2-macroglobulin from Yoshida sarcoma shortens erythrocyte survival. 11952820

2002

Entrez Id: 2
Gene Symbol: A2M
A2M
Experimental Autoimmune Encephalomyelitis
0.200 Therapeutic RGD Infusion of purified alpha 2 M effectively protected the rats against clinical EAE and this was associated with a restimulation of the acute-phase response. 1710603

1991

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0015814
Disease: Femur Head Necrosis
Femur Head Necrosis
0.200 Biomarker RGD New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model. 20579363

2010

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0015967
Disease: Fever
Fever
0.200 Biomarker RGD Fever was continuously recorded and 24 h after induction acute phase reactant (APR) response was measured as indicated by the rise of alpha-macrofetoprotein (alpha M FP, alpha 2 macroglobulin of the rat).Controls received 0.9% saline i.c.v. 2460123

1988

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0017665
Disease: Membranous glomerulonephritis
Membranous glomerulonephritis
0.200 Biomarker RGD Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms. 9453001

1998

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.200 Biomarker RGD Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. 12494268

2003

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0021368
Disease: Inflammation
Inflammation
0.200 Biomarker RGD Prostaglandin E1, a mediator of inflammation, was investigated for its effects on serum acute phase proteins, alpha 2 macroglobulin (alpha 2M). 6202298

1984

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.200 Biomarker RGD alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. 15509519

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0029823
Disease: Other specified peritonitis
Other specified peritonitis
0.200 Biomarker RGD Alpha-2-macroglobulin and albumin are useful serum proteins to detect subclinical peritonitis in the rat. 16538883

2006

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0041227
Disease: Trypanosomiasis
Trypanosomiasis
0.200 Biomarker RGD Alpha 2 macroglobulin activity in rats infected with Typanosoma lewisi and treated with cyclophosphamide and its effect on the malignancy of the disease. 17722867

2007

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma
0.200 Biomarker RGD alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. 15509519

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver
0.200 Biomarker RGD alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. 15509519

2004

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0600327
Disease: Toxic Shock Syndrome
Toxic Shock Syndrome
0.200 Therapeutic RGD Alpha 2 macroglobulin of the rat, an acute phase protein, mitigates the early course of endotoxin shock. 2424486

1986

Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0853897
Disease: Diabetic Cardiomyopathies
Diabetic Cardiomyopathies
0.200 Therapeutic RGD Beneficial effects of Psidium guajava leaf extract on diabetic myocardium. 21742475

2013

Entrez Id: 2
Gene Symbol: A2M
A2M
Hepatoblastoma Caused By Somatic Mutation
0.200 Biomarker RGD alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. 15509519

2004

Entrez Id: 65985
Gene Symbol: AACS
AACS
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Biomarker RGD Effects of streptozotocin-induced diabetes on acetoacetyl-CoA synthetase activity in rats. 12034369

2002

Entrez Id: 65985
Gene Symbol: AACS
AACS
CUI: C0028754
Disease: Obesity
Obesity
0.200 Biomarker RGD To clarify the effects of obesity on ketone body utilization in brain, we examined the mRNA localization of acetoacetyl-CoA synthetase (AACS), which activates ketone bodies for the synthesis of fatty acid and cholesterol, in various brain regions of Zucker fatty rats by in situ hybridization. 19219059

2009

Entrez Id: 15
Gene Symbol: AANAT
AANAT
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.200 Biomarker RGD Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes. 18624957

2008

Entrez Id: 15
Gene Symbol: AANAT
AANAT
Diabetes Mellitus, Non-Insulin-Dependent
0.200 Biomarker RGD Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. 16441550

2006