Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 AlteredExpression LHGDN Our data suggest that PTEN blocks Sp1 phosphorylation in response to HBx, by inactivating PKC, MAPK and MAPK kinase which eventually downregulate IGF-II expression, during the formation of HCC. 12804776

2003

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker LHGDN Equally, specific reduction of IGF-II was achieved using RNAinterference in HCC cells. 18035699

2005

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 AlteredExpression LHGDN Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population. 16857788

2006

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 GeneticVariation LHGDN IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection. 16750516

2006

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker LHGDN Of the informative HCC samples 47.06% (8 of 17) demonstrated a gain of imprinting of IGF2, and 21.74% (5 of 23) of the informative HCC samples demonstrated a loss of imprinting of H19. 18358696

2008

Entrez Id: 3481
Gene Symbol: IGF2
IGF2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.700 Biomarker LHGDN Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma. 18350600

2008