Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD To study the effects of suplatast tosilate (IPD) on the airway inflammation and expression of interleukin-5 in asthmatic rats. 25008888

2014

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Therapeutic RGD [Effects of suplatast tosilate on airway inflammation and interleukin-5 in asthmatic rats]. 25008888

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Many MMPs such as MMP-1, MMP-2, MMP-3 are associated with asthma, in which MMP-9 is the key factor in asthma. 16191269

2005

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule. 16540403

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD The protein and mRNA expression level of MMP-9 and TIMP-1 was high in asthmatic rat's lung tissues. 16191269

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD [Regulatory effects of inhaled steroids on expression of matrix metalloproteinase-9 and its inhibitor in asthmatic rats]. 16191269

2005

Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD 20 +/- 1.75)%] were all significantly higher than those of the control group [(1.51 +/- 1.04) x 10(7)/L, (0.70 +/- 0.48)%] (P < 0.01); the total cell numbers in BALF, the absolute numbers of EOS and EOS% of RA groups [(14.89 +/- 2.35) x 10(7)/L, (4.70 +/- 0.82)%; (10.98 +/- 1.81) x 10(7)/L, (3.56 +/- 0.53)%] were all significantly lower than those of asthma group (P < 0.01); (2) The concentration of IL-4 in BALF of asthma group (25.70 +/- 7.36) was significantly higher than that of the control group (8.55 +/- 2.97) (P < 0.01); the concentration of IL-4 of BALF of RA groups [(31.89 +/- 5.46), (35.26 +/- 6.03)] was significantly lower than that of asthma group (P < 0.01); the concentration of IL-12 of BALF of asthma group (16.10 +/- 3.38) was significantly lower than that of the control group (42.33 +/- 9.66) (P < 0.01); the concentration of IL-12 of BALF of the RA groups [(31.89 +/- 5.46), (35.26 +/- 6.03)] was significantly higher than that of the asthma group (P < 0.01); (3) Immunohistochemistry and in situ hybridization showed that the protein content of STAT4 and the STAT4 mRNA expression around the bronchus of asthma group [(0.096 +/- 0.012), (0.098 +/- 0.011)] were lower than those of the control group [(0.216 +/- 0.034), (0.228 +/- 0.032)], while those of RA groups [(0.176 +/- 0.012), (0.185 +/- 0.023); (0.183 +/- 0.011), (0.201 +/- 0.019)] were all significantly higher than that of the asthma group (P < 0.01), the airway smooth muscle cells, the pulmonary arterial smooth muscle cells and endothelial cells were the chief expression cells; (4) the STAT4 and the STAT4mRNA expression around the bronchus had positive correlation with the concentration of IL-12 in BALF while had negative correlation with the concentration of IL-4, absolute numbers of EOS in BALF. 18211752

2010

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD To explore the roles of interleukin-5 (IL-5) and eotaxin in signal transmission between lung and bone marrow in rat asthmatic models and to investigate the effects of different interventions on the signal transmission. 17074272

2006

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0004096
Disease: Asthma
Asthma
0.590 Biomarker RGD Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction. 17964702

2008

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Therapeutic RGD In situ hybridization showed that the mRNA expression of STAT6 around the bronchus of asthma group (0.180 +/- 0.013) was significantly higher than that of the control group (0.091 +/- 0.012) (P < 0.01), while that of DXM group (0.114 +/- 0.010) was significantly lower than that of asthma group. 16083555

2010

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Therapeutic RGD (3) Immunohistochemistry showed that the protein content of STAT6 around the bronchus of asthma group (0.171 +/- 0.025) was significantly higher than that of the control group (0.082 +/- 0.022) (P < 0.01), while that of DXM group (0.114 +/- 0.013) was significantly lower than that of asthma group.The epithelial cells were the cells. 16083555

2010

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Therapeutic RGD [Expression of signal transducer and activator of transcription 6 in rat asthma model and the modulatory effect of dexamethasone]. 16083555

2010

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Therapeutic RGD To study the expression of signal transducer and activator of transcription 6 and its mRNA in rat asthma model and the modulatory effect of dexamethasone (DXM). 16083555

2010

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker RGD The respiratory rate, expiratory flow, percentage of eosinophils in BALF inflammatory cells, peripheral blood IgE concentration, mRNA expression of STAT6 and NF-kappaB of the asthma group were (206 +/- 11) times/min, (77 +/- 8) microl/s, 24.8% +/- 1.3%, (72.5 +/- 8.1) ng/ml, 0.294 +/- 0.048, and 0.686 +/- 0.052 respectively, all significantly higher than those of the low dose treatment group [(183 +/- 9) times/min, (64 +/- 5) microl/s, 18.5% +/- 3.1%, (63.4 +/- 4.8) ng/ml, 0.229 +/- 0.038, and 0.613 +/- 0.062 respectively, all P < 0.05] and those of the high dose treatment group [(181 +/- 11) times/min, (57 +/- 4) microl/s, 14.7% +/- 2.1%, (41.4 +/- 7.4) ng/ml, 0.194 +/- 0.076, and 0.352 +/- 0.267, all P < 0.05]. 19087723

2009

Entrez Id: 6778
Gene Symbol: STAT6
STAT6
CUI: C0004096
Disease: Asthma
Asthma
0.400 Therapeutic RGD STAT6 protein and STAT6 mRNA were found strongly expressed in rat asthma model and the epithelial cells were the chief expressing cells. 16083555

2010

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD The expression of interleukin-17 (IL-17) in lung and peripheral blood of asthmatic rats and the influence of dexamethasone, and the role of IL-17 in the pathogenesis of asthma were investigated. 18060619

2007

Entrez Id: 6361
Gene Symbol: CCL17
CCL17
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD In contrast to the findings in the asthma and lung fibrosis models, the increased expression of MDC and TARC in the cigarette-smoke model was not associated with an increased infiltration of Th2 cells into smoke-treated lungs. 15993846

2005

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD The expression of IL-17 mRNA in PBMC and BALF cells of asthmatic rats was markedly increased as compared with normal rats and dexamethasone-interfered rats (P<0.01), and significant difference was found between normal rats and dexamethasone-interfered rats (P<0.05). 18060619

2007

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD Reduced airway inflammation in CD26/DPP4-deficient F344 rats is associated with altered recruitment patterns of regulatory T cells and expression of pulmonary surfactant proteins. 20560982

2010

Entrez Id: 4586
Gene Symbol: MUC5AC
MUC5AC
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD These results suggested that SO(2) could increase the expressions of MUC5AC and ICAM-1 on the transcription and translation levels in the lungs and tracheas from asthmatic rats, which might be one of the possible mechanisms that SO(2) pollution aggravates asthma disease. 17590487

2007

Entrez Id: 50616
Gene Symbol: IL22
IL22
CUI: C0004096
Disease: Asthma
Asthma
0.300 Therapeutic RGD High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism. 21998459

2012

Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD Thereby, we found a dose-dependent recruitment of cellular markers of allergic asthma including the activated CD4(+)/CD25(+)/CD26(+) T cell subpopulation, which has not been described in asthma yet. 17351063

2007

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD The percentage of CD4(+) CD25(+) Foxp3(+) Treg in the blood and the levels of IL-10 and TGF-beta in the plasma in cases of asthma group were significantly lower than that of the control and therapy group at different time points (P<0.05); The percentage of CD4(+) CD25(+) Foxp3(+) Treg and the level of IL-10 in lymph were significantly higher than that of blood (P<0.05), however, the level of TGF-beta in lymph were significantly lower than that of blood (P<0.05); There were no significant differences which the percentage of CD4(+) CD25(+) Foxp3(+) Treg in the blood and the levels of IL-10 and TGF-beta in the plasma between control group and therapy group (P>0.05). 20230687

2010

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0004096
Disease: Asthma
Asthma
0.300 Therapeutic RGD To observe the effects of medicinal extract for tonifying kidney to relieve asthma on glucocorticoid receptor (GR) expression in rats with asthma, and to explore its mechanism in treating asthma. 20727335

2010

Entrez Id: 7356
Gene Symbol: SCGB1A1
SCGB1A1
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD [Expression of Clara cell secretory protein in airways of rat asthma remodel]. 12921604

2003