Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.560 Biomarker RGD Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. 16846501

2006

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia. 21213399

2011

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD [Influence of JDTL injection on inflammatory factors in rat experimental cerebral ischemia]. 19260320

2008

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Therapeutic RGD Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. 18369388

2008

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. 17549754

2007

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia. 17101276

2007

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD Expression of interleukin-17 in ischemic brain tissue. 16305645

2005

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker CTD_mouse Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia. 15829914

2005

Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.510 Biomarker RGD In this study, the authors analyzed the expression pattern of interleukin-18, -1beta, and caspase-1 in focal brain ischemia induced in rats either by permanent middle cerebral artery occlusion or by photothrombosis of cortical microvessels. 11807395

2002

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.500 Biomarker RGD Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. 21718970

2011

Entrez Id: 7132
Gene Symbol: TNFRSF1A
TNFRSF1A
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.500 Biomarker RGD TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning. 16442237

2006

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.500 Biomarker RGD Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats. 12535784

2003

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.240 Biomarker RGD Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. 15353210

2004

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.230 Biomarker RGD Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation. 16882007

2006

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.230 Biomarker RGD RAGE is expressed in pyramidal cells of the hippocampus following moderate hypoxic-ischemic brain injury in rats. 12618340

2003

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia. 22036625

2012

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats. 21695352

2012

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. 21718970

2011

Entrez Id: 199
Gene Symbol: AIF1
AIF1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Time dependent changes of striatal interneurons after focal cerebral ischemia in rats. 18301954

2008

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Altered expression of sodium transporters in ischemic penumbra after focal cerebral ischemia in rats. 17662498

2007

Entrez Id: 6546
Gene Symbol: SLC8A1
SLC8A1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.220 Biomarker RGD Altered gene expression of Na+/Ca2+ exchanger isoforms NCX1, NCX2 and NCX3 in chronic ischemic rat brain. 12377375

2002

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Therapeutic RGD Combination of Ligusticum chuanxiong and Radix Paeoniae ameliorate focal cerebral ischemic in MCAO rats via endoplasmic reticulum stress-dependent apoptotic signaling pathway. 27108052

2016

Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Therapeutic RGD Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. 23644141

2013

Entrez Id: 4842
Gene Symbol: NOS1
NOS1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. 21718970

2011

Entrez Id: 4891
Gene Symbol: SLC11A2
SLC11A2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Tanshinone IIA prevented brain iron dyshomeostasis in cerebral ischemic rats. 21325818

2011