Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0009319
Disease: Colitis
Colitis
0.600 Therapeutic RGD TGP attenuates TNBS/ethanol-induced colitis in rats and its efficacy is similar to SASP, the potential mechanism might be related to the adjustment of Th1/Th2 cytokines polarization by decreasing pro-inflammatory cytokine TNF-α and IL-1β, and increasing anti-inflammatory cytokine IL-10. 23771723

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009319
Disease: Colitis
Colitis
0.600 Biomarker RGD Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. 22969190

2012

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0009319
Disease: Colitis
Colitis
0.600 Biomarker RGD Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. 21949848

2011

Entrez Id: 3605
Gene Symbol: IL17A
IL17A
CUI: C0009319
Disease: Colitis
Colitis
0.600 Biomarker RGD Bovine glycomacropeptide has intestinal antiinflammatory effects in rats with dextran sulfate-induced colitis. 20881082

2010

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009319
Disease: Colitis
Colitis
0.600 Therapeutic RGD Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. 17543437

2007

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0009319
Disease: Colitis
Colitis
0.570 Biomarker RGD A vegetal ALA-rich formula decreases the expression of ICAM-1, VCAM-1, and VEGFR-2 and independently of HO-1 in rats with TNBS-induced colitis. 22261574

2012

Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0009319
Disease: Colitis
Colitis
0.570 Therapeutic RGD BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats. 21853095

2011

Entrez Id: 5970
Gene Symbol: RELA
RELA
CUI: C0009319
Disease: Colitis
Colitis
0.550 Biomarker RGD Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis. 18623154

2008

Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0009319
Disease: Colitis
Colitis
0.530 Biomarker RGD Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis. 16866779

2006

Entrez Id: 4282
Gene Symbol: MIF
MIF
CUI: C0009319
Disease: Colitis
Colitis
0.510 Biomarker RGD Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. 17324399

2007

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0009319
Disease: Colitis
Colitis
0.300 Biomarker RGD In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS). 19002562

2009

Entrez Id: 64127
Gene Symbol: NOD2
NOD2
CUI: C0009319
Disease: Colitis
Colitis
0.300 Biomarker RGD In this study, we examined the kinetics of Card15/Nod2 expression in intestinal tissue during inflammation in the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-treated rat experimental colitis model. 16891783

2006

Entrez Id: 6863
Gene Symbol: TAC1
TAC1
CUI: C0009319
Disease: Colitis
Colitis
0.290 Biomarker RGD During the acute phases of colitis, a marked decrease in tissue SP and NKA levels were observed along with an increased transcription of beta-PPT mRNA in the neurons of the myenteric plexus and an increased myeloperoxidase activity, which is an index of the tissue's inflammatory status. 18715640

2009

Entrez Id: 4583
Gene Symbol: MUC2
MUC2
CUI: C0009319
Disease: Colitis
Colitis
0.260 Therapeutic RGD Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. 23395625

2013

Entrez Id: 4583
Gene Symbol: MUC2
MUC2
CUI: C0009319
Disease: Colitis
Colitis
0.260 Therapeutic RGD Tumor necrosis factor-α and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. 21949848

2011

Entrez Id: 4583
Gene Symbol: MUC2
MUC2
CUI: C0009319
Disease: Colitis
Colitis
0.260 Biomarker RGD Reduction of MUC2 expression in colitis rats was reversed by muscovite and 5-ASA treatment. 19220658

2009

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0009319
Disease: Colitis
Colitis
0.250 Biomarker RGD Chemokines IL-8 and MCP-1 are elevated in mucosal tissues in colitis and play an important role in the perpetuation of tissue destructive inflammatory processes; melatonin reduces colonic inflammatory injury of rats colitis through down-regulating the expressions of chemokines. 18690297

2008

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0009319
Disease: Colitis
Colitis
0.240 Biomarker RGD Mesenteric adipose tissue alterations resulting from experimental reactivated colitis. 17604368

2007

Entrez Id: 7412
Gene Symbol: VCAM1
VCAM1
CUI: C0009319
Disease: Colitis
Colitis
0.230 Biomarker RGD Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. 22261574

2012

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0009319
Disease: Colitis
Colitis
0.230 Biomarker RGD Estrogen receptor-β signaling modulates epithelial barrier function. 21252046

2011

Entrez Id: 6402
Gene Symbol: SELL
SELL
CUI: C0009319
Disease: Colitis
Colitis
0.230 Biomarker RGD Trinitrobenzene sulfonic acid/dinitrobenzene sulfonic acid (TNBS/DNBS)-induced colitis was studied in rats on treatment with anti-L-selectin monoclonal antibodies (mAb) or antineutrophil antiserum. 18054560

2007

Entrez Id: 958
Gene Symbol: CD40
CD40
CUI: C0009319
Disease: Colitis
Colitis
0.230 Biomarker RGD Their involvement in the pathogenesis of chronic inflammatory bowel disease (IBD) has been revealed by increased expression of CD40 and CD154 in the inflamed mucosa of patients and the therapeutic effects of anti-CD154 antibodies in experimental colitis. 15591506

2005

Entrez Id: 4436
Gene Symbol: MSH2
MSH2
CUI: C0009319
Disease: Colitis
Colitis
0.220 Biomarker RGD Together with the histological changes associated with acute colitis, APE1 and MSH2 levels increased significantly at 3 and 5 days after DSS treatment, respectively. 23883737

2013

Entrez Id: 3791
Gene Symbol: KDR
KDR
CUI: C0009319
Disease: Colitis
Colitis
0.220 Biomarker RGD A vegetal ALA-rich formula decreases the expression of ICAM-1, VCAM-1, and VEGFR-2 and independently of HO-1 in rats with TNBS-induced colitis. 22261574

2012

Entrez Id: 1395
Gene Symbol: CRHR2
CRHR2
CUI: C0009319
Disease: Colitis
Colitis
0.220 Biomarker RGD Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2. 21330446

2011