|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.900 |
Biomarker |
CLINGEN |
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.
|
27329137 |
2016 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.900 |
Biomarker |
CLINGEN |
Cancer risks for MLH1 and MSH2 mutation carriers.
|
23255516 |
2013 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.900 |
Biomarker |
CLINGEN |
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.
|
17101317 |
2006 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.900 |
Biomarker |
CLINGEN |
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.
|
8706033 |
1996 |
|
| Entrez Id: |
4436 |
| Gene Symbol: |
MSH2 |
MSH2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.900 |
Biomarker |
CLINGEN |
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer.
|
8261515 |
1993 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Lynch syndrome caused by germline PMS2 mutations: delineating the cancer risk.
|
25512458 |
2015 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer.
|
22494821 |
2012 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.
|
20624957 |
2010 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.
|
18790734 |
2008 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations.
|
18602922 |
2008 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Endonucleolytic function of MutLalpha in human mismatch repair.
|
16873062 |
2006 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Long-range PCR facilitates the identification of PMS2-specific mutations.
|
16619239 |
2006 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer).
|
15872200 |
2005 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Familial mutations in PMS2 can cause autosomal dominant hereditary nonpolyposis colorectal cancer.
|
15887124 |
2005 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer.
|
11793442 |
2002 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant.
|
11709755 |
2002 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
MSH6 and MSH3 are rarely involved in genetic predisposition to nonpolypotic colon cancer.
|
11245474 |
2001 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.
|
10545954 |
1999 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.
|
10521294 |
1999 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer.
|
9354786 |
1997 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
|
9390556 |
1997 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.
|
7604265 |
1995 |
|
| Entrez Id: |
2956 |
| Gene Symbol: |
MSH6 |
MSH6
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
|
7604264 |
1995 |
|
| Entrez Id: |
5395 |
| Gene Symbol: |
PMS2 |
PMS2
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.640 |
Biomarker |
CLINGEN |
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
|
8072530 |
1994 |
|
| Entrez Id: |
27030 |
| Gene Symbol: |
MLH3 |
MLH3
|
Hereditary Nonpolyposis Colorectal Neoplasms
|
0.500 |
Biomarker |
CLINGEN |
Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome.
|
19156873 |
2009 |