Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression. 27106565

2016

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Therapeutic RGD Compared with the CUS+vehicle rats, the CUS+VPA rats showed a significant relief in depression-like behaviors and a decrease in the corticosterone level and corticotropin-releasing factor expression with increasing expression of BDNF. 24128869

2014

Entrez Id: 7166
Gene Symbol: TPH1
TPH1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD The results indicate that there exists possible interrelation between TH and TPH gene expression and epigenetic histone acetylation in CUS-induced depressive rats, which at least partly contributes to the etiology of depression. 24495952

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD In the present study, we aimed to investigate the effect of Interleukin-6 (IL-6) on colon motility in a rat model of depression induced by chronic unpredictable mild stress (CUMS). 23589140

2013

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. 22406386

2012

Entrez Id: 6281
Gene Symbol: S100A10
S100A10
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment. 21682946

2012

Entrez Id: 4915
Gene Symbol: NTRK2
NTRK2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD [Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. 22097208

2011

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. 20860876

2011

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD [Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. 22097208

2011

Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Importantly, Par-4 and DRD2 mRNA levels significantly correlated with depression-like behaviors. 21596067

2011

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. 21843601

2011

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD [Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress]. 21837980

2011

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. 20860876

2011

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Therapeutic RGD The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. 19623606

2010

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat. 20920483

2010

Entrez Id: 6530
Gene Symbol: SLC6A2
SLC6A2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Here we sought to determine if alpha-Syn, or the other synuclein family members, beta-synuclein (beta-Syn) and gamma-synuclein (gamma-Syn), modulate NET activity in an animal model of depression, the Wistar-Kyoto (WKY) rat. 18800064

2009

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD For that reason we hypothesized that homozygous 5-HT transporter knockout rat (SERT(-/-)) models, especially female, are valuable and reliable animal models for humans with an increased vulnerability for anxiety- and depression-related disorders. 18295409

2008

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD The genetic association database. 15118671

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Reserpine induced behavioral depression partially via brain interleukin-1 beta generation. 15000880

2004

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.580 Therapeutic RGD Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex. 19815943

2010

Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.580 Biomarker RGD Using the olfactory bulbectomized (OB) rat model of depression, this study evaluated two pathways from bulbectomy to the induction of depression-like changes (the inflammation-hypothalamic-pituitary-adrenal axis-stress response pathway and inflammation-nerve growth factor-memory pathway) and the effect of EPA on these pathways. 19129380

2009

Entrez Id: 1129
Gene Symbol: CHRM2
CHRM2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.540 Biomarker RGD Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours. 20830301

2010

Entrez Id: 150
Gene Symbol: ADRA2A
ADRA2A
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.530 Biomarker RGD Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. 20047711

2010

Entrez Id: 1621
Gene Symbol: DBH
DBH
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.530 Biomarker RGD Degeneration of the locus ceruleus noradrenergic neurons in the stress-induced depression of rats. 19120095

2008

Entrez Id: 1812
Gene Symbol: DRD1
DRD1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.530 Biomarker RGD Isolated Flinders Sensitive Line rats have decreased dopamine D2 receptor mRNA. 17558292

2007