Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.550 Biomarker RGD Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats. 19948880

2010

Entrez Id: 183
Gene Symbol: AGT
AGT
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.550 ModifyingMutation RGD Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats. 15888567

2005

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.510 Biomarker RGD During GN a reduction of CLR and RAMP 2 + 3 expressions was detected on days 3, 7 and 14, while RAMP 1 rose.ADM mRNA decreased on days 3 and 7. 20431304

2010

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.510 Biomarker RGD Then, we made an anti-glomerular basement membrane (GBM) GN rat model and compared the AM expression and production in each glomeruli obtained from the control or m-PSL-treated anti-GBM GN rats. 16735801

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Therapeutic RGD Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. 11318962

2001

Entrez Id: 6346
Gene Symbol: CCL1
CCL1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Biomarker RGD Effective methylprednisolone dose in experimental crescentic glomerulonephritis. 11157384

2001

Entrez Id: 6354
Gene Symbol: CCL7
CCL7
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.500 Biomarker RGD Effective methylprednisolone dose in experimental crescentic glomerulonephritis. 11157384

2001

Entrez Id: 1285
Gene Symbol: COL4A3
COL4A3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.340 Biomarker RGD Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis. 11158397

2001

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Therapeutic RGD Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture. 21718676

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. 20406136

2010

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD Podocyte repopulation contributes to regression of glomerular injury induced by ACE inhibition. 19164508

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.240 Biomarker RGD Differential regulation of glomerular gelatinase B (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in obese Zucker rats. 9300240

1997

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Biomarker RGD Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation. 27129290

2016

Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Therapeutic RGD Effects of combination PPARγ agonist and angiotensin receptor blocker on glomerulosclerosis. 26999660

2016

Entrez Id: 718
Gene Symbol: C3
C3
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.230 Biomarker RGD Involvement of dipeptidyl peptidase IV in immune complex-mediated glomerulonephritis. 11950907

2002

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Biomarker RGD The protective effect of BHR on renal function in rats with GS is possibly by way of influencing expressions of TGF-beta1, TIMP-1 and MMP1 to regulate the state of extracellular matrix and lessen the matrix aggregation. 21275176

2010

Entrez Id: 4312
Gene Symbol: MMP1
MMP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Biomarker RGD NMDA receptor-mediated activation of NADPH oxidase and glomerulosclerosis in hyperhomocysteinemic rats. 20406136

2010

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Biomarker RGD The role of the renin-angiotensin system in cholesterol and puromycin mediated renal injury. 12495295

2002

Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.220 Therapeutic RGD Rats with progressive mesangioproliferative glomerulonephritis were treated from day 3 to day 7 after disease induction with a high-affinity oligonucleotide aptamer antagonist against platelet-derived growth factor-B chain (PDGF-B). 11316849

2001

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. 21907828

2013

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats. 22207560

2012

Entrez Id: 80310
Gene Symbol: PDGFD
PDGFD
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Thus, podocyte-specific overexpression of PDGF-D caused mesangioproliferative disease, glomerulosclerosis, and crescentic glomerulonephritis. 21866094

2011

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 ModifyingMutation RGD Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. 20720406

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. 12675855

2003

Entrez Id: 2353
Gene Symbol: FOS
FOS
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.210 Biomarker RGD Retinoid receptor-specific agonists alleviate experimental glomerulonephritis. 11880336

2002