Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. 25583186

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. 25510949

2015

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Variants of the CRP gene thus influence circulating CRP levels and appear as independent susceptibility factors for late-life depression. 25603415

2015

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET TNF-α -308G/A and IL-8 -251T/A were significantly associated with AD and IL-1β +3953C/T with late-life depression, while the significance of these associations was lost after Bonferroni correction. 25315113

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasing hormone receptor 1 (CRHR1) genes in African American children. 25422957

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Our findings reveal that 5-HTTLPR polymorphism modulates distressed feelings and brain activities associated with negative self-schema and suggest a potential neurogenetic susceptibility mechanism for depression. 23588187

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Epigenetic and epistatic interactions between serotonin transporter and brain-derived neurotrophic factor genetic polymorphism: insights in depression. 24972302

2014

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Variants of the ACE gene influence cortisol secretion and appear as susceptibility factors for late-life depression in the elderly population. 24193727

2013

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET In this study, we tested the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-α), and neuroplasticity (brain-derived neurotrophic factor (BDNF), p11 and VGF), in healthy controls (n=34) and depressed patients (n=74), before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-based Therapeutic Drugs for Depression study. 22990943

2013

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET The associations between physical disorders and incident depression were significant in the presence of 2 alleles related to higher proinflammatory cytokine production (tumor necrosis factor-α -850T and IL-8 -251A), and 1 allele related to lower anti-inflammatory cytokine production (IL-4 +33C). 22921153

2013

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Genetic variations in interleukin-8 and interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. 23149083

2013

Entrez Id: 1401
Gene Symbol: CRP
CRP
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. 22683764

2012

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population. 22688325

2012

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET We detected intensive DNA methylation within a recently described, functional important region of the ACE gene promoter including hypermethylation in depressed patients (p = 0.008) and a significant inverse correlation between the ACE serum concentration and ACE promoter methylation frequency in the total sample (p = 0.02). 22808171

2012

Entrez Id: 6281
Gene Symbol: S100A10
S100A10
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET These results suggest that p11 loss in rodent and human nucleus accumbens may contribute to the pathophysiology of depression. 20962330

2010

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET Logistic regression analyses showed that after controlling for epidemiologic (age and sex), clinical (stage of disease, comorbidities), and symptom (depressed mood and fatigue) variables known to influence pain severity, variant alleles in IL-8 -251T/A [odds ratio (OR), 2.35; 95% confidence interval (95% CI), 1.10-5.03; P = 0.03] persisted as a significant factor for severe pain for White patients. 18086782

2007

Entrez Id: 551
Gene Symbol: AVP
AVP
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.400 Biomarker PSYGENET In the melancholic subgroup, AVP mRNA expression was significantly increased in both the SON and the PVN compared with control subjects. 16499879

2006

Entrez Id: 1137
Gene Symbol: CHRNA4
CHRNA4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.340 Biomarker PSYGENET Study findings identified a significant link between the CHRNA4:rs1044396 polymorphism and depression and loneliness in the aged. 22008229

2012

Entrez Id: 1137
Gene Symbol: CHRNA4
CHRNA4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.340 Biomarker PSYGENET We identified a significant epistasis effect BCL1 by CHRNA4 showing that carriers of the CC genotype at the BCL1 locus who were also homozygous for the T allele at the CHRNA4 locus had the highest depression scores. 22760121

2012

Entrez Id: 1137
Gene Symbol: CHRNA4
CHRNA4
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.340 Biomarker PSYGENET Thus, we also briefly review data generated from genetically modified mice to support a role for discrete nAChR subunits in anxiety disorders, depression, and schizophrenia. 18690103

2008

Entrez Id: 796
Gene Symbol: CALCA
CALCA
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.330 Biomarker PSYGENET We investigate effects on neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) like immunoreactivity (LI) in 10 brain regions as these neuropeptides are affected by antidepressants and are altered in cerebrospinal fluid of depressed patients. 16600456

2006

Entrez Id: 4615
Gene Symbol: MYD88
MYD88
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.320 Biomarker PSYGENET Based on the current results, it seems that chronic inflammation in depressed patients correlates to the over expression of TRIF and MYD88 genes. 24168294

2014

Entrez Id: 140691
Gene Symbol: TRIM69
TRIM69
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.310 Biomarker PSYGENET Based on the current results, it seems that chronic inflammation in depressed patients correlates to the over expression of TRIF and MYD88 genes. 24168294

2014

Entrez Id: 5806
Gene Symbol: PTX3
PTX3
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.310 Biomarker PSYGENET The densitometric analysis of slot blots showed that the mean steady-state mRNA level of PTX3 was 3.5-fold higher in the melancholic group as compared to that in normal controls and in nonmelancholic depressives (n=8, all groups). 14603263

2004

Entrez Id: 7297
Gene Symbol: TYK2
TYK2
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.300 Biomarker PSYGENET Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. 20124106

2010