Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.400 Biomarker PSYGENET Patients with frontotemporal lobar degeneration with the C9ORF72 repeat expansion are more likely than those without to present with psychosis. 23036583

2013

Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.400 Biomarker PSYGENET Detailed histories revealed a higher prevalence of psychosis, including visual and auditory hallucinations and delusions, in the 8 C9ORF72 carriers than in our patients with sporadic FTD. 24077574

2013

Entrez Id: 203228
Gene Symbol: C9orf72
C9orf72
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.400 Biomarker PSYGENET The repeat expansion in C9ORF72 is a common cause of FTLD and often presents with late-onset psychosis or memory impairment. 23473366

2013

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.390 Biomarker PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287

2014

Entrez Id: 10846
Gene Symbol: PDE10A
PDE10A
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.350 Biomarker PSYGENET PDE10A has been implicated in the pathophysiology of psychosis. 22205951

2011

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.350 Biomarker PSYGENET Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis. 15864111

2005

Entrez Id: 2643
Gene Symbol: GCH1
GCH1
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 Biomarker PSYGENET Also, when we compare the FEP patients after risperidone treatment with controls, this difference remains significant, and no significant differences were observed in GCH1 mRNA levels when comparing patients before and after risperidone treatment. 25270546

2014

Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 Biomarker PSYGENET To examine the role of FKBP5-trauma interactions in the partly stress-related psychosis phenotype. 23429203

2013

Entrez Id: 811
Gene Symbol: CALR
CALR
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 Biomarker PSYGENET We have recently reported mutations in the CALR promoter that co-occur with psychosis. 22507216

2012

Entrez Id: 811
Gene Symbol: CALR
CALR
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.330 Biomarker PSYGENET Reversion of the human calreticulin gene promoter to the ancestral type as a result of a novel psychosis-associated mutation. 21182888

2011

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis. 24275585

2014

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis. 24016415

2014

Entrez Id: 1394
Gene Symbol: CRHR1
CRHR1
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating. 24166410

2014

Entrez Id: 80312
Gene Symbol: TET1
TET1
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET Increased TET1 and decreased APOBEC3A and APOBEC3C found in this study highlight the possible role of altered DNA demethylation mechanisms in the pathophysiology of psychosis. 22948384

2012

Entrez Id: 64067
Gene Symbol: NPAS3
NPAS3
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET Our identification of potentially defective NPAS3 variants supports recent studies that implicate perturbations in NPAS3 pathways in impaired neurogenesis and psychosis. 20466522

2010

Entrez Id: 81565
Gene Symbol: NDEL1
NDEL1
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET DISC1, a promising candidate susceptibility gene, encodes a protein which interacts with many other proteins, including CIT, NDEL1, NDE1, FEZ1 and PAFAH1B1, some of which also have been associated with psychosis. 20084519

2010

Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET Our findings may also implicate the whole family of HERG channels (HERG1, HERG2 and HERG3) in the pathogenesis of psychosis and its treatment. 20507645

2010

Entrez Id: 3757
Gene Symbol: KCNH2
KCNH2
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target. 19412172

2009

Entrez Id: 1555
Gene Symbol: CYP2B6
CYP2B6
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T. 17968817

2007

Entrez Id: 1745
Gene Symbol: DLX1
DLX1
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET Patients with a history of psychosis showed significantly decreased relative numbers of DLX1-positive neurons compared with patients without history of psychosis and nonpsychiatric controls (P =.02), whereas no differences could be found in relative numbers of SHOX2-positive neurons (P>.15). 12963668

2003

Entrez Id: 9968
Gene Symbol: MED12
MED12
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.320 Biomarker PSYGENET In an effort to determine whether other allelic polymorphisms in this gene exist and may potentially contribute to increased susceptibility to neuropsychiatric illness, we have performed single stranded conformational polymorphism (SSCP) analysis of all 45 exons and each of the two potential promoter regions of HOPA using DNA from a panel of patients with psychosis. 14582143

2003

Entrez Id: 57144
Gene Symbol: PAK5
PAK5
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.310 Biomarker PSYGENET We demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity. 24474471

2014

Entrez Id: 947
Gene Symbol: CD34
CD34
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.310 Biomarker PSYGENET Furthermore, in the SG, the number of circulating Lin(-)/CD45(-)/CD34(+) VSELs and the S1P plasma level are the best predictors of risk and are proposed as novel markers for the first "schizophrenic" episode of psychosis. 24246416

2014

Entrez Id: 26011
Gene Symbol: TENM4
TENM4
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.310 Biomarker PSYGENET Our findings show ODZ4 as a risk gene for SCZ, emphasizing the existence of common vulnerability in psychosis. 25124521

2014

Entrez Id: 5788
Gene Symbol: PTPRC
PTPRC
CUI: C0349204
Disease: Nonorganic psychosis
Nonorganic psychosis
0.310 Biomarker PSYGENET Furthermore, in the SG, the number of circulating Lin(-)/CD45(-)/CD34(+) VSELs and the S1P plasma level are the best predictors of risk and are proposed as novel markers for the first "schizophrenic" episode of psychosis. 24246416

2014