Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Several of the affected genes were known to be associated with aggressive prostate cancer such as loss of PTEN, CDH1, BCAR1 and gain of MYC. 29295717

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human The long tail of oncogenic drivers in prostate cancer. 29610475

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). 29335545

2018

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. 28319090

2017

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human Overall, this study demonstrates that AR-Vs broadly restore AR chromatin binding events that are otherwise suppressed during endocrine therapy, and provides pre-clinical rationale for BET inhibition as a strategy for inhibiting expression and chromatin binding of AR-Vs in PCa. 25908785

2015

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160

2015

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Overall, this study demonstrates that AR-Vs broadly restore AR chromatin binding events that are otherwise suppressed during endocrine therapy, and provides pre-clinical rationale for BET inhibition as a strategy for inhibiting expression and chromatin binding of AR-Vs in PCa. 25908785

2015

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human Integrative molecular profiling of routine clinical prostate cancer specimens. 25735316

2015

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160

2015

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Integrative molecular profiling of routine clinical prostate cancer specimens. 25735316

2015

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC). 25062956

2014

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC). 25062956

2014

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human We confirmed that AR directly regulates c-Myc transcription in a ligand-independent manner, that AR and c-Myc suppression reduces ligand-independent prostate cancer cell growth, and that ectopic expression of c-Myc attenuates the anti-growth effects of AR suppression. 23704919

2013

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human We confirmed that AR directly regulates c-Myc transcription in a ligand-independent manner, that AR and c-Myc suppression reduces ligand-independent prostate cancer cell growth, and that ectopic expression of c-Myc attenuates the anti-growth effects of AR suppression. 23704919

2013

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human In this study, we investigated the role of SIRT1 in multiple human prostate cancer cell lines and prostate-specific PTEN knockout mouse model using resveratrol. 23248098

2013

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Successful Treatment of Advanced Metastatic Prostate Cancer following Chemotherapy Based on Molecular Profiling. 22666205

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice. 22581815

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Common genetic alterations in prostate cancer include losses of NKX3.1 (8p21) and PTEN (10q23), gains of AR (the androgen receptor gene) and fusion of ETS family transcription factor genes with androgen-responsive promoters. 22610119

2012

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Common genetic alterations in prostate cancer include losses of NKX3.1 (8p21) and PTEN (10q23), gains of AR (the androgen receptor gene) and fusion of ETS family transcription factor genes with androgen-responsive promoters. 22610119

2012

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human Common genetic alterations in prostate cancer include losses of NKX3.1 (8p21) and PTEN (10q23), gains of AR (the androgen receptor gene) and fusion of ETS family transcription factor genes with androgen-responsive promoters. 22610119

2012

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Therapeutic CTD_human Successful Treatment of Advanced Metastatic Prostate Cancer following Chemotherapy Based on Molecular Profiling. 22666205

2012

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Since these miRNAs target PTEN (phosphatase and tensin homolog deleted on chromosome 10), we performed Western blot to confirm up-regulation of PTEN in PCa cells. 21714127

2011

Entrez Id: 5728
Gene Symbol: PTEN
PTEN
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
1.000 Biomarker CTD_human Regulation of phosphatase homologue of tensin protein expression by bone morphogenetic proteins in prostate epithelial cells. 21456062

2011