Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Therapeutic RGD Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. 23700476

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental
0.500 Therapeutic RGD Simultaneous disruption of estrogen receptor and Wnt/β-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats. 24078029

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental
0.500 Biomarker RGD Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15637090

2005

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.400 Therapeutic RGD [The expression of estrogen receptor alpha and beta in the intervention of different estrogens in rat bone metabolism]. 16955786

2006

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.300 Biomarker RGD Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. 23608653

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker RGD Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. 22230815

2012

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.300 Biomarker RGD Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. 19141699

2009

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.250 Therapeutic RGD Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. 24631553

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.250 Therapeutic RGD Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. 24128867

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.250 Therapeutic RGD Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats. 24015243

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.250 Biomarker RGD However, ERB-041 has a dramatic beneficial effect in the HLA-B27 transgenic rat model of inflammatory bowel disease and the Lewis rat adjuvant-induced arthritis model. 14500559

2003

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0004096
Disease: Asthma
Asthma
0.240 Biomarker RGD ERB-041 [7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-1,3-benzoxazol-5-ol], an ERbeta agonist, was profiled on cytokine release from interleukin-1beta-stimulated human airway smooth muscle (HASM) cells and in the rodent asthma model. 18375789

2008

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.230 Therapeutic RGD Impact of estrogen receptor beta activation on functional recovery after experimental stroke. 24406718

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0009319
Disease: Colitis
Colitis
0.230 Biomarker RGD Estrogen receptor-β signaling modulates epithelial barrier function. 21252046

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0521170
Disease: Osteoporotic Fractures
Osteoporotic Fractures
0.220 Biomarker RGD Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing. 25085540

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0600142
Disease: Hot flushes
Hot flushes
0.220 Therapeutic RGD Novel ligands balance estrogen receptor β and α agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. 24823389

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia
0.210 Biomarker RGD Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. 10414967

1999

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0042035
Disease: Urination Disorders
Urination Disorders
0.200 Therapeutic RGD Effects of agonists for estrogen receptor α and β on ovariectomy-induced lower urinary tract dysfunction in the rat. 24259512

2014

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Periodic 17β-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-β. 23593292

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0029823
Disease: Other specified peritonitis
Other specified peritonitis
0.200 Therapeutic RGD Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. 23063870

2013

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0154088
Disease: Carcinoma in situ of prostate
Carcinoma in situ of prostate
0.200 Therapeutic RGD Opposing roles of ERα and ERβ in the genesis and progression of adenocarcinoma in the rat ventral prostate. 22025007

2012

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.200 Biomarker RGD Estrogen rescues preexisting severe pulmonary hypertension in rats. 21700911

2011

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0273115
Disease: Lung Injury
Lung Injury
0.200 Biomarker RGD Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. 20195535

2010

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0010692
Disease: Cystitis
Cystitis
0.200 Biomarker RGD The effect of tamoxifen on bladder functions and histology, and the role of estrogen receptor beta in a rat chemical cystitis model. 16894621

2007

Entrez Id: 2100
Gene Symbol: ESR2
ESR2
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.200 Biomarker RGD An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain. 17056036

2006