Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker RGD Fever and formation of TNF-α and IL-6 induced by intraperitoneal injections of MALP-2 (1000 µg/kg) were completely blunted in TLR2-KO, while LPS (100 µg/kg)-induced responses were not abolished in these animals. 22042912

2012

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker RGD This study examined the effects of exercise training (ExT) upon concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in the gastrocnemius of rats with heart failure (HF) induced by left coronary artery ligation. 28939262

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD This study examined the effects of exercise training (ExT) upon concentration of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-10 (IL-10) in the gastrocnemius of rats with heart failure (HF) induced by left coronary artery ligation. 28939262

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression. 27106565

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker RGD In the present study, we aimed to investigate the effect of Interleukin-6 (IL-6) on colon motility in a rat model of depression induced by chronic unpredictable mild stress (CUMS). 23589140

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker RGD Excessive food intake, obesity and inflammation process in Zucker fa/fa rat pancreatic islets. 21826222

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker RGD Role of inflammatory cytokines and chemoattractants in the rat model of streptozotocin-induced diabetic heart failure. 18999900

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker RGD SHR displayed early stage of heart failure as shown by increased heart weight/body weight ratio and relative wall thickness by echocardiography, downregulated myocardial beta(1)-adrenoceptor, and upregulated myocardial brain natriuretic peptide and interleukin-6 (IL6). 18280594

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD SHR displayed early stage of heart failure as shown by increased heart weight/body weight ratio and relative wall thickness by echocardiography, downregulated myocardial beta(1)-adrenoceptor, and upregulated myocardial brain natriuretic peptide and interleukin-6 (IL6). 18280594

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.600 Biomarker RGD Role of inflammatory cytokines and chemoattractants in the rat model of streptozotocin-induced diabetic heart failure. 18999900

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker RGD IL-6 plasma bioactivity correlated significantly with spleen weight and weight loss, implicating IL-6 in the cachectic response. 9110147

1997

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.580 Biomarker RGD Dynamic response to peripheral nerve injury detected by in situ hybridization of IL-6 and its receptor mRNAs in the dorsal root ganglia is not strictly correlated with signs of neuropathic pain. 23953943

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.580 Biomarker RGD Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain. 18988309

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0021368
Disease: Inflammation
Inflammation
0.570 Therapeutic RGD Aqueous extract of Rosmarinus officinalis L. inhibits neutrophil influx and cytokine secretion. 25319517

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic RGD Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. 29498696

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Biomarker RGD Beneficial effects of physical training on the cardio-inflammatory disorder induced by lung ischemia/reperfusion in rats. 20680426

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic
0.500 Biomarker RGD Results show that haemorrhagic shock increases plasma AST and ALT concentrations, hepatic myeloperoxidase activity, cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-3, intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) levels. 21168948

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD Regulation of IRS-2 signaling by IGF-1 receptor in the diabetic rat heart. 20555424

2010

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD Effects of rosiglitazone and aspirin on experimental model of induced type 2 diabetes in rats: focus on insulin resistance and inflammatory markers. 19328014

2010

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. 18976114

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 Therapeutic RGD The hydrogen sulfide releasing compounds ATB-346 and diallyl trisulfide attenuate streptozotocin-induced cognitive impairment, neuroinflammation, and oxidative stress in rats: involvement of asymmetric dimethylarginine. 27088818

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0014544
Disease: Epilepsy
Epilepsy
0.300 Biomarker RGD Higher levels of proinflammatory cytokines(IL-1β, IL-6, TNF-α) were found both in the brain tissue and the serum in the epilepsy rats of each group. 28303499

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Biomarker RGD Effects of melatonin on cytokine release and healing of colonic anastomoses in an experimental sepsis model. 27598601

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0243026
Disease: Sepsis
Sepsis
0.300 Therapeutic RGD Moxifloxacin-loaded nanoemulsions having tocopheryl succinate as the integral component improves pharmacokinetics and enhances survival in E. coli-induced complicated intra-abdominal infection. 25317848

2014