Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker RGD Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats. 21847581

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0004096
Disease: Asthma
Asthma 		0.600 Biomarker RGD Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule. 16540403

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker RGD Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat. 15773227

2005
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker RGD Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. 15665729

2005
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.570 Biomarker RGD Inducible nitric oxide synthase mediates retinal DNA damage in Goto-Kakizaki rat retina. 18773271

2009
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.560 Biomarker RGD Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. 21171972

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.540 Biomarker RGD Beneficial effects of magnolol in a rodent model of endotoxin shock. 20519137

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.540 Biomarker RGD In this study, we examined changes in gene expression of iNOS in various regions of the intestine as well as the distribution of iNOS protein in the intestinal cells in a rat model of endotoxemia produced by intraperitoneal injection of lipopolysaccharide (LPS; 10 mg/kg). 16787348

2005
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0009319
Disease: Colitis
Colitis 		0.530 Biomarker RGD Expression of iNOS mRNA associated with suppression of colonic contraction in rat colitis. 16866779

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.510 Biomarker RGD Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats. 21903766

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.500 Biomarker RGD Ammonia reduction with ornithine phenylacetate restores brain eNOS activity via the DDAH-ADMA pathway in bile duct-ligated cirrhotic rats. 21903766

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD The neuroprotective effect of agmatine after focal cerebral ischemia in diabetic rats. 21993016

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker RGD Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection. 21844074

2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0600327
Disease: Toxic Shock Syndrome
Toxic Shock Syndrome 		0.500 Biomarker RGD Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock. 16601845

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker RGD Expression and role of inducible nitric oxide synthase in ischemia-reperfusion liver in rats. 14599979

2003
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0003949
Disease: Asbestosis
Asbestosis 		0.500 Biomarker RGD Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase. 12051993

2002
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker RGD Effect of exogenous melatonin on hepatic energetic status during ischemia/reperfusion: possible role of tumor necrosis factor-alpha and nitric oxide. 11592783

2001
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker RGD Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats. 10784593

2000
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker RGD Increased nitric oxide synthase expression in aorta of cirrhotic rats. 10353629

1999
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.300 Biomarker RGD The role of NOS in the impairment of spatial memory and damaged neurons in rats injected with amyloid beta 25-35 into the temporal cortex. 21163295

2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.260 Biomarker RGD Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis. 21958875

2011
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0242350
Disease: Erectile dysfunction
Erectile dysfunction 		0.230 Biomarker RGD Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence. 19554009

2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension 		0.220 ModifyingMutation RGD Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension. 16113050

2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.210 Biomarker RGD Protective effects of ulinastatin on acute liver failure induced by lipopolysaccharide/D-galactosamine. 22001939

2012
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.210 Biomarker RGD A crucial role of nitric oxide in acute lung injury secondary to the acute necrotizing pancreatitis. 20144956

2010