Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. 18288891

2008

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Thus, p27(Kip1) contributes to beta-cell failure during the development of type 2 diabetes in Irs2(-/-) and Lepr(-/-) mice and represents a potential new target for the treatment of this condition. 15685168

2005

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD It has been reported that insulin receptor substrate (IRS)-1 deficient (IRS-1-/-) mice showed insulin resistance without type 2 diabetes, whereas the IRS-2 deficient (IRS-2-/-) mice showed insulin resistance with type 2 diabetes. 12810606

2003

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling system coordinates peripheral insulin action and pancreatic beta cell function, so mice lacking Irs2 display similarities to humans with type 2 diabetes. 14617753

2003

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. 11812758

2002

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation. 11259600

2001

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD IRS-2 pathways integrate female reproduction and energy homeostasis. 11014193

2000

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Although homozygous IRS-2-deficient mice (IRS-2-/- mice) had a body weight similar to wild-type mice, they progressively developed type 2 diabetes at 10 weeks. 11078455

2000

Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker MGD Our results indicate that dysfunction of IRS-2 may contribute to the pathophysiology of human type 2 diabetes. 9495343

1998