DisGeNET - a database of gene-disease associations

Source: CLINGEN

Disease: Breast Cancer, Familial ×

Gene: XRCC2 ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	7516
Gene Symbol:	XRCC2

XRCC2

CUI:	C0346153
Disease:	Breast Cancer, Familial

Breast Cancer, Familial

0.530

Biomarker

CLINGEN

Rare mutations in XRCC2 increase the risk of breast cancer.

22464251

2012

Entrez Id:	7516
Gene Symbol:	XRCC2

XRCC2

CUI:	C0346153
Disease:	Breast Cancer, Familial

Breast Cancer, Familial

0.530

Biomarker

CLINGEN

Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice.

14678973

2003

Entrez Id:	7516
Gene Symbol:	XRCC2

XRCC2

CUI:	C0346153
Disease:	Breast Cancer, Familial

Breast Cancer, Familial

0.530

Biomarker

CLINGEN

Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice.

11118202

2000

Entrez Id:	7516
Gene Symbol:	XRCC2

XRCC2

CUI:	C0346153
Disease:	Breast Cancer, Familial

Breast Cancer, Familial

0.530

Biomarker

CLINGEN

The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.

10422536

1999