Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. 19096302

2009

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma. 18334834

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma. 18303429

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Mutations of EGFR and K-ras genes represent an early event in lung adenocarcinomagenesis, and AAH convincingly seems to be a precursor lesion in a subset of cases of adenocarcinoma. 18208799

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN The prevalence of mutant KRAS2, inactivation of TP53 and SMAD4, and aberrant DNA methylation of a seven-gene panel is similar in familial pancreatic adenocarcinomas as in sporadic pancreatic adenocarcinomas. 19064568

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Thus, KRAS polymorphisms were indicated to be involved in risk for the development of AAHs that progress to ADC by causing differential KRAS oncogene expression in the lungs. 18299280

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN KRAS2 gene mutations are found in 75-90% of infiltrating pancreatic ductal adenocarcinomas but can also be present with other nonneoplastic pancreatic diseases. 18075308

2008

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution. 17575320

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker LHGDN Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line. 17352027

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression LHGDN RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. 17638924

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Among adenocarcinomas, nonmucinous and mucinous BAC components were significantly associated with EGFR and K-ras gene mutations, respectively. 17580276

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Missense mutations in KRAS codon 12 were detected in six of seven (86%) mucinous adenocarcinomas but only 3 of 18 (17%) nonmucinous adenocarcinomas (P = 0.003). 17591931

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 PosttranslationalModification LHGDN The frequency of KRAS mutation and RASSF1A methylation were significantly different between adenocarcinomas (P<0.001) and squamous cell carcinomas (P<0.001). 17360030

2007

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Prostate adenocarcinomas with a BRAF mutation tended to show higher preoperative serum PSA levels, Gleason scores and tumor stages than prostate adenocarcinomas with a KRAS mutation. 16721785

2006

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Usefulness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis. 15608367

2004

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 PosttranslationalModification LHGDN These results showed that the majority of the primary NSCLCs with Kras2 mutations lack RASSF1A inactivation, and both RASSF1A inactivation and Kras2 mutation events occur frequently in adenocarcinomas and large cell carcinomas. 14511407

2004

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity. 15367885

2004

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN KRAS2 mutations were found in four out of 19 (21%) Barrett's adenocarcinomas examined and in three cases of HGIN (11%). 14724583

2004

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status. 14508142

2003

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas. 12606951

2003

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation LHGDN A case of pancreatic adenocarcinoma with novel K-ras mutation and long term survival. 12135058

2002