Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN The insertion polymorphism in angiotensin-converting enzyme gene associated with the APOE epsilon 4 allele increases the risk of late-onset Alzheimer disease. 17401152

2006

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN We have investigated the effect of ACE I/D polymorphism in 351 AD and 155 VD patients and 348 healthy controls. 15722183

2005

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors. 15917098

2005

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN Alzheimer disease risk and genetic variation in ACE: a meta-analysis. 14872014

2004

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN Shifts in angiotensin I converting enzyme insertion allele frequency across Europe: implications for Alzheimer's disease risk. 12876265

2003

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN Further research is needed to elucidate any role that the DCP1 polymorphism may play in relation to Alzheimer's disease. 12605101

2003

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD. 12928053

2003

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.900 GeneticVariation LHGDN ACE genotypes associated with the risk of AD, but II genotype as risk genetic factor only restricted in subjects with high blood pressure. 12362316

2002