Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 Biomarker LHGDN Progression to AD and hippocampal volumetric loss was greatest in participants who carried both APOE epsilon4 and BCHE-K alleles and lowest in BCHE-K carriers without the APOE epsilon4 allele. 18334913

2008

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 GeneticVariation LHGDN Interaction between estrogen receptor-alpha and butyrylcholinesterase genes modulates Alzheimer's disease risk. 17410321

2007

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 GeneticVariation LHGDN Butyrylcholinesterase, ApoE and Alzheimer's disease in a population from the Canary Islands (Spain). 17923322

2007

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 Biomarker LHGDN Butyrylcholinesterase attenuates amyloid fibril formation in vitro. 16731619

2006

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 Biomarker LHGDN We tested the premise that cholinesterase inhibitor therapy should target butyrylcholinesterase (BuChE) in Alzheimer's disease (AD), not acetylcholinesterase (AChE) alone, because both enzymes hydrolyze acetylcholine, and BuChE is increased in AD cerebral cortex. 16278840

2006

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 PosttranslationalModification LHGDN The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients. 15802910

2005

Entrez Id: 590
Gene Symbol: BCHE
BCHE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.400 GeneticVariation LHGDN Analysis of association between butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease. 15519745

2004