Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. 18853337

2008

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Our results provide further evidence for the potential importance of the glutamate receptor GRM3 in schizophrenia, and indicate that the novel antipsychotic LY2140023 may actually be targeting a pathogenic pathway of schizophrenia. 18614340

2008

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression LHGDN This is the first experimental evidence that mGlu3 receptor levels are altered in schizophrenia and supports the hypothesis that neurotransmission involving this particular excitatory amino acid receptor is impaired in schizophrenia. 17531207

2007

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function. 17636131

2007

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The existence of the GRM3Delta4 isoform is relevant in the light of the reported association of non-coding single nucleotide polymorphisms (SNPs) in GRM3 with schizophrenia, and with the potential of GRM3 as a therapeutic target for several neuropsychiatric disorders. 16417579

2006

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN The principle finding of this study is that GRM3 polymorphisms were collectively significant predictors of negative symptom improvement in persons with schizophrenia treated with the atypical antipsychotic olanzapine. 15913960

2005

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker LHGDN In a family-based association study, a common GRM3 haplotype was strongly associated with schizophrenia (P = 0.0001). 15310849

2004

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN We focused on the metabotropic glutamate receptor type 3 gene (GRM3) as a candidate for schizophrenia susceptibility. 12782962

2003

Entrez Id: 2913
Gene Symbol: GRM3
GRM3
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation LHGDN Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population. 11840505

2002