Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 AlteredExpression LHGDN Cell surface LHR expression in stable transformants of the ErbB-2-overexpressing ovarian cancer cell line SKOV3 was confirmed by PCR and whole-cell ligand binding studies. 19010824

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 Biomarker LHGDN The CTLs were capable of lysing low doses of peptides pulsed into target cells or OC Her-2/neu(+) tumors. 19115932

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 PosttranslationalModification LHGDN DNA methylation of tumor suppressor genes is a frequent event in ovarian cancer, and in some cases is associated with Her-2/neu overexpression. 18757082

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 GeneticVariation LHGDN Genomic alteration of the HER2-neu and EGFR genes is frequent (25%) in ovarian cancer. 18182111

2008

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 Biomarker LHGDN Taken together, our findings strongly suggest that N-WASP plays a pivotal role in regulating HA-mediated CD44-ErbB2 interaction, beta-catenin signaling, and actin cytoskeleton functions that are required for tumor-specific behaviors and ovarian cancer progression. 17092940

2007

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 GeneticVariation LHGDN In our selected set of tumors, the Val allele was overrepresented in the subset of HER2-positive breast cancers and the Ile allele in serous ovarian cancer. 16682283

2006

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 GeneticVariation LHGDN We hypothesize that HER2 genotypes can be predictive biomarkers in ovarian cancer, contributing to a genetic individual profile of great interest in clinical oncology. 16112085

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 Biomarker LHGDN Levels of CA15.3 in breast cancer and CA125 in ovarian cancer were significantly higher in cases expressing c-erbB-2 (p < 0.01) than in negative c-erbB-2 cases. 14563447

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 AlteredExpression LHGDN Abnormalities of epidermal growth factor receptor (EGFR) and Her-2/neu have been actively investigated in ovarian cancer and associated with unfavorable clinical outcome. 11972392

2002

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.700 AlteredExpression LHGDN ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin. 12174876

2002