Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD The murine beige mutant phenotype and the human Chediak-Higashi syndrome are caused by mutations in the murine Lyst (lysosomal trafficking regulator) gene and the human CHS gene, respectively. 16518687

2006

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Lung pathology of pale ear mouse (model of Hermansky-Pudlak syndrome 1) and beige mouse (model of Chediak-Higashi syndrome): severity of giant lamellar body degeneration of type II pneumocytes correlates with interstitial inflammation. 15743322

2005

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Slate--a new coat color mutant in the mouse. 13943454

1998

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Cytoarchitectonic abnormalities in cerebellum and hippocampal formation of beige mutant mouse. 1523694

1992

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD The beige mouse: role of neutrophil elastase in the development of pulmonary emphysema. 2806196

1989

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Lysosomal mutations increase susceptibility to anaesthetics. 2513223

1989

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. 3584547

1987

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity. 7089489

1982

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Defective T-cell response in beige mutant mice. 6977094

1982

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Leishmaniasis in beige mice. 6218091

1982

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD The origin and fate of large dense bodies in beige mouse fibroblasts. Lysosomal fusion and exocytosis. 6170520

1981

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. 7366734

1980

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Role of NK cells in tumour growth and metastasis in beige mice. 7366733

1980

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. 489978

1979

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Formation of anomalous lysosomes in monocytes, neutrophils, and eosinophils from bone marrow of mice with Chédiak-Higashi syndrome. 1113502

1975

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Defective lysosomal enzyme secretion in kidneys of Chediak-Higashi (beige) mice. 408

1975

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome. 4697831

1973

Entrez Id: 1130
Gene Symbol: LYST
LYST
CUI: C0007965
Disease: Chediak-Higashi Syndrome
Chediak-Higashi Syndrome
1.000 Biomarker MGD Giant granules in leukocytes of the beige mouse. 5590154

1968