Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET Genetic analyses of the level of response to alcohol, particularly of the functional OPRM1 A118G polymorphism and 5' and 3' functional polymorphisms in SLC6A4, are beginning to provide insights into the etiology of alcoholism and also genotype-stratified subgroup responses to naltrexone and SSRIs/ondansetron respectively. 24220019

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET The findings in this meta-analysis suggest that the SLC6A4 promoter polymorphism is not associated with alcohol dependence. 25710844

2015

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET We previously reported moderating effects of age of onset of alcohol dependence (AD) and a functional polymorphism (5-HTTLPR) in the gene encoding the serotonin transporter protein in a sample of 134 individuals participating in a 12-week, placebo-controlled trial of sertraline. 23145795

2014

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET These findings reveal significant interactive effects among variants in SLC6A4-HTR3A-HTR3B affecting AD. 23757001

2013

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic
0.600 Biomarker PSYGENET Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). 22460318

2012