Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Network modeling and animal experiments suggest that these genetic differences in GR-induced transcriptional activation may mediate the risk for depression and other psychiatric disorders by altering a network of functionally related stress-sensitive genes in blood and brain. 26050039

2015

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Methylation in CpG sites in candidate genes were not predictors of depression at significance levels corrected for whole genome testing, but maltreated and control children did have significantly different β values after Bonferroni correction at multiple methylation sites in these candidate genes (e.g., BDNF, NR3C1, FKBP5). 24655651

2014

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoid receptor sensitivity, stress response regulation, and depression risk in traumatized subjects, with most consistent findings reported for the functional variant rs1360780. 25522420

2014

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET We investigated PTSD and depression severity, plasma cortisol, GR and mineralocorticoid receptor (MR) levels, and methylation status of NR3C1 and NR3C2 promoter regions in 25 women exposed to the Tutsi genocide during pregnancy and their children, and 25 women from the same ethnicity, pregnant during the same period but not exposed to the genocide, and their children. 24690014

2014

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.600 Biomarker PSYGENET Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression. 25358426

2014