Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker PSYGENET Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population. 24262814

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker PSYGENET The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. 25290268

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker PSYGENET Further imaging genetic investigations on the mediating effect of CACNA1C in schizophrenia can uncover brain circuitries involved in schizophrenia and suggest potential novel targets for intervention. 25470093

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker PSYGENET Since CACNA1C variants have been associated repeatedly with psychosis at a genome-wide level, and preclinical data provide convergent evidence for the relevance of the CACNA1C gene for hippocampal and frontolimbic plasticity and adaptive regulation of stress, our data suggest a potential pathophysiological mechanism conferred by CACNA1C variants that may mediate risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24642287

2014