Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2625
Gene Symbol: GATA3
GATA3
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD The results showed that an increase of Th2 cytokine and an inhibition of Th1 cytokine were accompanied by an increased expression of GATA-3 protein and a decreased expression of T-bet protein in rat asthmatic airways compared to those in normal control group. 18186587

2007

Entrez Id: 2625
Gene Symbol: GATA3
GATA3
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD Intraperitoneal ligustrazine administration could significantly lower the level of IL-4 in BALF and the expression of GATA-3 protein in lung and also increase the level of IFN-gamma and T-bet in asthmatic rats, resulting in a decreased percentage of eosinophils (EOS) in BALF and ameliorated airway inflammatory cell infiltration. 18186587

2007

Entrez Id: 2625
Gene Symbol: GATA3
GATA3
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker RGD In conclusion, ligustrazine inhibits OVA induced airway inflammation by modulating key master switches GATA-3 and T-bet that result in reversing the Th2 cytokine patterns in asthma. 18186587

2007