Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE (3) Also, the neu gene encoded protein p185 has been associated with a more aggressive clinical course in adenocarcinomas. 1962774

1990

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinoma. 10665910

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER-2/neu overexpression was detected in 27% of the tumors of different histological types including adenocarcinomas, large cell carcinomas, and squamous cell carcinomas. 10928158

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER-2/neu is overexpressed on a variety of human adenocarcinomas and overexpression has been associated with a poor prognosis. 10965998

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 positivity by at least one of the three techniques was most common in adenocarcinomas, at 29% (42 of 143). 14614004

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER-2/neu overexpression was significantly associated with histologic subtype: 19 adenocarcinomas (19/82, 23%) versus 4 squamous cell carcinomas (4/44, 9%) overexpressed Her-2/neu (P = 0.04). 14639106

2003

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER2-neu overexpression was found in 19 tumors (17.1%) and was significantly more common in adenocarcinomas than in squamous cell carcinomas (P = 0.035). 14734462

2004

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER-2/neu is overexpressed in approximately one-third of esophageal adenocarcinomas. 15581047

2004

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations were significantly more frequent in never smokers (3.2%, 8 of 248; P=0.02) and adenocarcinoma histology (2.8%, 11 of 394; P=0.003). 15753357

2005

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER-2/neu and TOPOIIalpha amplification/overexpression might discriminate between BO and dysplasia/ADC. 20557373

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE Her-2 protein expression was investigated in 341 esophageal carcinomas [152 squamous cell carcinomas (SCC), 189 adenocarcinomas (AC)], 39 cases of Barrett mucosa, and 11 cases of squamous cell dysplasia. 21107094

2010

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker CTD_human HER2 Testing in Gastric/Gastroesophageal Junction Adenocarcinomas: Unique Features of a Familiar Test. 21673877

2011

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 in situ hybridization in gastric and gastroesophageal adenocarcinoma: comparison of automated dual ISH to FISH. 23455182

2013

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 expression is consistently absent in gastric NECs, regardless of HER2 amplification status or association with HER2-positive adenocarcinoma/dysplasia components. 24329753

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2-dependent signalling pathway is deregulated in a subset of colon adenocarcinomas. 24659651

2014

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations were detected in 46 (3.6%) of the NSCLCs, with mutations only present in the ADC. 25468202

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 positivity occurs in 15.6 % of invasive gastroesophageal adenocarcinoma in Western patients, of which the majority is esophageal primary tumors and of the intestinal tumor type. 25544671

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Human epidermal growth factor receptor 2 testing in gastric and gastroesophageal junction adenocarcinomas: role of the gastroenterologist. 25805465

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2-positive (HER2(+)) breast adenocarcinomas are a heterogeneous group in which hormone receptor (HR) status influences therapeutic decisions and patient outcome. 26227964

2015

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 insertion could define a distinct subset of NSCLC, which had a higher prevalence among females, nonsmokers, and adenocarcinoma. 27008586

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations are observed in mucinous adenocarcinoma and adenocarcinoma with micropapillary features. 27403614

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 status is an independent prognostic biomarker in gastroesophageal adenocarcinomas receiving epirubicin-based chemotherapy. 27530622

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations were more frequently encountered in females, non-smokers and adenocarcinoma. 27825109

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. 27841667

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. 28077399

2016