Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Aβ<sub>25-35</sub> -induced changes in Ca<sup>2+</sup> and B-cell lymphoma-2 (Bcl-2) and Bcl-2-associated X (Bax) protein and gene levels in cells were also reversed by genistein. 30450837

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Furthermore,the associated mitochondrial cleaved‑caspase 3, poly‑ADP ribose polymerase (PARP), caspase 9 and Bcl‑2‑associated X protein levels increased while B‑cell lymphoma‑2 (Bcl‑2) decreased both in the cell and animal ART‑treated group. 29901098

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE To understand upstream signaling mechanisms, we have determined the effect of NF-kappaB blockade on the status of different Bcl-2 (B-cell lymphoma 2) proteins in this study. 15135541

2004

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Pro-apoptotic protein, Bcl-2 associated × (Bax), exhibited a slight, but significant decrease with rapamycin treatment, while its anti-apoptotic counterpart, B cell lymphoma-2 (Bcl-2), was to a similar degree upregulated. 30594149

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Aquaporin 3 knockdown suppressed tumour proliferation, marked by enhanced expression of p53, an increased ratio of cleaved caspase 3 to pro-caspase 3 and reduced expression of proliferating cell nuclear antigen and B-cell lymphoma-2 (bcl-2). 24803527

2014

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Furthermore, administration of fisetin suppressed neuron cell death and apoptosis, increased the expression of B-cell lymphoma 2 (Bcl-2), while decreased the expression of Bcl-2-associated X protein (Bax) and caspase-3 after TBI. 29792955

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Phase 1 study of lenalidomide plus dose-adjusted EPOCH-R in patients with aggressive B-cell lymphomas with deregulated MYC and BCL2. 30707764

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Several other molecules are currently being evaluated such as cyclin dependent kinase 4/6 (CDK4/6), phosphoinositide 3-kinase (PI3K), B cell lymphoma-2 (BCL2) and Poly ADP-ribose polymerase (PARP) inhibitors. 26689790

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE In addition, FFJ-3 treatment increased the ratio of B-cell lymphoma-2 (Bcl-2)/Bcl-2 associated X and activated the caspase-3 cascade. 28454440

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Expression levels of p-ERK1/2, permeability glycoprotein (P-gp), B-cell lymphoma 2 (Bcl-2), Bcl-XL, Bax and Bad protein were detected in the different ovarian cancer cells by western blotting. 26794135

2016

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE After different concentrations of UDCA treatment, the mRNA and protein expressions of caspase-3, caspase-8, caspase-9, Bax, Fas/FasL (Fas ligand), TRAIL (TNF-related apoptosis-inducing ligand), DR4 (death receptor 4) and DR5 (death receptor 5) were increased in HSC-3 cells, and mRNA and protein expressions of Bcl-2 (B-cell lymphoma 2), Bcl-xL (B-cell lymphoma-extra large), XIAP (X-linked inhibitor of apoptosis protein), cIAP-1 (cellular inhibitor of apoptosis 1), cIAP-2 (cellular inhibitor of apoptosis 2) and survival were decreased. 25951128

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE We also found using western blot that cleaved caspase3 and B cell lymphoma 2 (Bcl2)-associated X protein abundances increased, whereas Bcl2 abundance decreased. 28640008

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Proteins of the B-cell lymphoma-2 (BCL-2) family control the intrinsic apoptosis pathway. 28676391

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Moreover, the expression levels of Bcl-2-associated X, and caspases-3 and -9 were downregulated, with a concomitant upregulation of B cell lymphoma 2 (P < .05). 29474123

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Translocation of the B-cell lymphoma/leukemia-2 ( bcl-2) gene was also examined. 15060790

2004

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis were applied to detect the expression levels of apoptosis-related factors, including activated-Caspase-3, B-cell lymphoma/leukemia-2 (Bcl-2) and Bcl-2 associated X (Bax), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) and total ERK1/2. 30186408

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Chromatin immunoprecipitation assay and luciferase reporter assay revealed that GATA4 was a transcription factor that activated mouse double minute 2 homolog (MDM2) and B cell lymphoma 2 (BCL2) expression in ALL cells. 28849107

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE MANF was mainly expressed in rat neurons, and its expression increased significantly at 3 h after SAH induction and peaked at 24 h. Stereotactic injection of rh-MANF into the cerebroventricle significantly increased the level of MANF, p-Akt, p-mouse double minute 2 homolog (p-MDM2), and B-cell lymphoma 2 (Bcl-2) in brain tissue, whereas it down-regulated the expression of P53, Bcl-2-associated X protein (Bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed. 30211660

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE The present study demonstrated that simvastatin inhibited the proliferation of MDA-MB-231 human breast cancer cells in a dose-dependent manner, decreased the protein expression of B cell lymphoma 2 (Bcl-2) and increased the protein expression of Bcl-2-associated X protein in time- and dose-dependent manners. 25738368

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE We correlated immunohistochemical expression of mTOR with germinal center and nongerminal center phenotype, B cell lymphoma-2 (bcl-2) and cellular homolog of the retroviral v-myconcogene (c-myc) expression, and International Prognostic Index (IPI) score in 31 patients with diffuse large B-cell lymphoma (DLBCL). 25458080

2015

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE Western blot was carried out to measure the protein expression level of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax). 30657568

2019

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 GeneticVariation BEFREE Recently, clonal heavy chain immunoglobulin (IgH) gene rearrangement and bcl-2 gene translocation have been reported in systemic B-cell lymphoma and are used for the detection of malignant cells and in making a diagnosis. 9754175

1998

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Here we demonstrate that necrosis of Mtb-infected Mϕ is dependent on the action of the cytosolic Receptor Interacting Protein Kinase 3 (RIPK3) and the mitochondrial Bcl-2 family member protein B-cell lymphoma-extra large (Bcl-x<sub>L</sub>). 28401933

2017

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 AlteredExpression BEFREE The proteins expression of apoptotic-related proteins Bcl-2 associated X (Bax), B cell lymphoma 2 (Bcl-2), optic-atrophy-1 (OPA1), mitofusin2 (Mfn2), phosphorylated dynamin-related protein 1 at serine 616 (p-DRP1), and total dynamin-related protein 1 (Total-DRP1) were also determined. 30078226

2018

Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas
0.100 Biomarker BEFREE Double-hit B-cell lymphoma is a common designation for a group of tumors characterized by concurrent translocations of MYC and BCL2, BCL6, or other genes. 26573234

2016