Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE We also demonstrate particularly high VPF/VEGF mRNA levels in several human tumors, where it may be involved in promoting tumor angiogenesis and stroma generation, both as an endothelial cell mitogen and indirectly by its permeability enhancing effect that leads to the deposition of a provisional fibrin gel matrix. 1550962

1992

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Crucial in tumor angiogenesis are the paracrine actions of tumor-secreted factors (e.g., vascular endothelial growth factor), which have been thought to derive from the tumor epithelial cells themselves. 7525053

1994

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Since flt-1 and KDR are not expressed in endothelial cells in the normal adult brain, the coordinate up-regulation of 2 receptors for VEGF appears to be a critical event which controls tumor angiogenesis. 7525492

1994

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE These data support previous reports, which stated that VEGF/VPF acts as a paracrine growth and permeability factor in brain tumors and may contribute to tumor growth by initiating tumor angiogenesis. 7528359

1994

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE These findings thus suggest that VEGF may be a positive factor in tumor angiogenesis in both human gliomas and meningiomas. 7532545

1995

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. 7553632

1995

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE This indicates that elF-4E-induced VPF expression may be an important factor in some forms of tumor angiogenesis and development. 8631593

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is a multifunctional cytokine that has been shown to be an important regulator of tumor angiogenesis. 8667614

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a multifunctional cytokine that is an important regulator of tumor angiogenesis. 8697391

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Thus, the vascular endothelial growth factor-signaling system seems to be an appropriate target for inhibition of tumor angiogenesis and metastasis formation. 8806195

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE Elevated vascular endothelial growth factor (VEGF) levels are required for ocular and tumor angiogenesis in animal models. 8833917

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE This data supports the assertion that angiogenetic factor such as bFGF and VEGF may contribute to progressive change of astrocytoma by tumor angiogenesis. 8835763

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE The prominence of VEGF mRNA levels in human ovarian and endometrial tumors demonstrates that VEGF may be involved in promoting tumor angiogenesis and stroma generation, acting as an endothelial cell mitogen. 9032563

1996

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE The findings indicate that mutant ras-oncogene-dependent VEGF/VPF expression is necessary, but not sufficient, for progressive tumor growth in vivo and highlight the relative contribution of oncogenes, such as mutant K-ras, to the process of tumor angiogenesis. 9520413

1998

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is thought to take an important role in tumor angiogenesis. 9657098

1998

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE These results not only support VEGF receptors as antiangiogenic targets but also demonstrate that sflt-1 gene therapy might be a feasible approach for inhibiting tumor angiogenesis and growth. 9671758

1998

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE Taken together, our results suggest a new pathway of cell signaling through PKC zeta and provide an insight into PKC zeta and Sp1-dependent transcriptional regulation of VPF/VEGF expression and thus tumor angiogenesis. 9756852

1998

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Although the function of Tie2 and its ligands in tumor angiogenesis remains a subject of speculation, our findings are in agreement with a recently proposed hypothesis that in the presence of VEGF, local production of Ang-2 might promote angiogenesis. 9811337

1998

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular endothelial growth factor-induced tumor angiogenesis and tumorigenicity in relation to metastasis in a HT1080 human fibrosarcoma cell model. 10048976

1999

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and an important prognostic factor in breast cancer. 10375015

1999

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Nude mouse xenografts revealed that interference with either the VEGF receptor pathway or the Tie-2 pathway resulted in a significant inhibition of tumor growth and tumor angiogenesis. 10397264

1999

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 AlteredExpression BEFREE Infection with a recombinant replication-defective adenovirus vector containing the cDNA of wild-type p16 significantly reduced the expression of vascular endothelial growth factor, which is thought to be a pivotal mediator of tumor angiogenesis, in p16-deleted glioma cells. 10446996

1999

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE In this article, we demonstrated that VEGF is participated in the tumor angiogenesis of hepatocellular carcinoma, esophageal cancer, and pancreatic cancer. 10457902

1999

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is a specific mitogen for vascular endothelial cells and has been implicated in tumor angiogenesis. 10558913

1999

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis
0.100 GeneticVariation BEFREE Its expression in sarcoma cells was reported to up-regulate the vascular endothelial growth factor (VEGF) gene and thereby enhance tumor angiogenesis, which is essential to tumor metastasis. 10640960

2000