Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE 5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes. 15718261

2005

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE AMP-activated kinase (AMPK) is a major regulator of energy metabolism and a promising target for development of new treatments for type 2 diabetes and cancer. 30230919

2018

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Clinical application of ACMG-AMP guidelines in HNF1A and GCK variants in a cohort of MODY families. 28170077

2017

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE Determination of the crystal structure of AMP-activated protein kinase (AMPK) is fundamental to understanding its biological function and role in a number of diseases related to energy metabolism including type 2 diabetes, obesity, and cancer. 29480465

2018

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Effect of AMP-activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population. 28322508

2018

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Finally, 2 months of therapy with the antidiabetic drug metformin significantly inhibited the maturation of IL-1β in MDMs from patients with type 2 diabetes through AMP-activated protein kinase (AMPK) activation. 23086037

2013

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE It has been proposed that the energy-sensing enzyme AMP-activated protein kinase (AMPK) is a key agent in the pathophysiology of type 2 diabetes mellitus (T2DM). 27427333

2017

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Newer drug targets such as protein kinase B (Akt/PKB), AMP-activated protein kinase (AMPK), sirtuin (SIRT), and others are novel approaches that act via different mechanisms and possibly treating T2DM of distinct variations and aetiologies. 29696964

2018

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Pharmacological activation of AMP activated kinase (AMPK) by metformin has proven to be a beneficial therapeutic approach for the treatment of type II diabetes. 22766107

2013

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Resveratrol was reported to increase insulin sensitivity accompanied with the activation of AMP-activated protein kinase (AMPK), which is a key regulator of energy balance and an important drug target for type 2 diabetes. 18434188

2008

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE S-AMP is, thus, an insulin secretagogue capable of reversing β cell dysfunction in T2D. 26411681

2015

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) is involved in cellular stress responses linked to obesity and type 2 diabetes. 19652946

2009

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). 28647324

2017

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE The serine/threonine kinase AMP-activated protein kinase (AMPK) is a drug target for the treatment of obesity and type 2 diabetes (T2D). 31836952

2019

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of animal models of type 1 and type 2 diabetes. 30545741

2019

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 AlteredExpression BEFREE We also discuss the activation of AMP activated protein kinase (AMPK) by the most widely used drug for type 2 diabetes, metformin, which exerts a dual negative regulatory effect on mTOR and BMP signaling, suggesting that metformin is a promising drug treatment for HO. 30989716

2019

Entrez Id: 4236
Gene Symbol: MFAP1
MFAP1
Diabetes Mellitus, Non-Insulin-Dependent
0.100 Biomarker BEFREE We have shown that the iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynojirimycin (AMP-DNM), an inhibitor of the enzyme glucosylceramide synthase, is a potent enhancer of insulin signaling in rodent models for insulin resistance and type 2 diabetes. 19072830

2009