Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Herein, we demonstrate HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2. 26172293

2015

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE HIF-1 activates genes that allow the cancer cell to survive and grow in the hostile hypoxic tumor environment. 15141023

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Hypoxia Inducible Factor 1 (HIF-1) is the main transcription factor that mediates the cell response to hypoxia through different mechanisms that include the regulation of genes strongly associated with cancer aggressiveness. 23947803

2013

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Its functional requirement for HIF-1 activity was also demonstrated in several different cancer cell lines, but AMPK activation alone was not sufficient to stimulate the HIF-1 transcriptional activity. 12900407

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE This study provides a basis for developing new biology-based clinically relevant strategies to improve the efficacy of radiation oncology, using HIF-1 as an ally for cancer therapy. 17557121

2007

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Since increased HIF-1 expression correlates with advanced disease stage, increased angiogenesis and poor prognosis, HIF-1 and its signaling pathway have become targets for cancer chemotherapy. 16596228

2006

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Hypoxia inducible factor 1 (HIF-1) is a major transcription factor that mediates adaptation of cancer cells to a hypoxic environment and regulates many genes that are involved in key cellular functions, including cell immortalization, stem cell maintenance, autocrine growth/survival, angiogenesis, invasion/metastasis, and resistance to chemotherapy. 25920936

2015

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization. 28761052

2017

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE We found that the expression of the apoptosis inhibitor ARC (apoptosis repressor with a CARD domain) was induced by hypoxia in a variety of cancer cell types, and its induction is primarily HIF1 dependent. 24344197

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism. 26801746

2016

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Finally, we describe the prevalence of SETD2-inactivating mutations in cancer, with the highest frequency in clear cell Renal Cell Cancer, and explore how SETD2-inactivation might contribute to tumor development. 27191891

2016

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Cetuximab inhibits HIF-1-regulated glycolysis in cancer cells, thereby reversing the Warburg effect and leading to inhibition of cancer cell metabolism. 27693630

2017

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays essential roles in human diseases including cancer. 31392931

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. 18766298

2008

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Hypoxia-inducible factor 1 (HIF-1) regulates the transcription of many genes involved in key aspects of cancer biology, including immortalization, maintenance of stem cell pools, cellular dedifferentiation, genetic instability, vascularization, metabolic reprogramming, autocrine growth factor signaling, invasion/metastasis, and treatment failure. 17933687

2007

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Aberrant Huntingtin interacting protein 1 in lymphoid malignancies. 17875735

2007

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE There is significant evidence that inhibition of HIF-1 would be beneficial for cancer therapy. 27978620

2017

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Tenascin-C is involved in promotion of cancer stemness via the Akt/HIF1ɑ axis in esophageal squamous cell carcinoma. 30904401

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Taken together, we illustrate multiple SETD2-regulated cellular pathways that suppress cancer development and uncover mechanisms underlying aberrant cell cycle regulation in SETD2-depleted cells. 30487242

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE The hypoxia-inducible factor-1 (HIF-1) plays a critical role in tumor adaptation to hypoxia, and its elevated expression correlates with poor prognosis and treatment failure in patients with cancer. 22923450

2012

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is regulated by the hypoxia-inducible factor 1 (HIF1) pathway and is implicated in tumor progression and patient survival in many types of cancer. 15086970

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Vascular Endothelial Growth Factor (VEGF) and its transcriptional regulator Hypoxia-inducible Factor 1 (HIF-1) play an important role in the process of angiogenesis in many types of cancer, including ovarian cancer. 17498666

2007

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance. 30634433

2019

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Identifying the role of STAT3 in the hypoxia response provides further data supporting the effectiveness of STAT3 inhibitors in solid tumor treatment owing to their usefulness in inhibiting both the STAT3 and HIF1 pro-tumorigenic signaling pathways in some cancer types. 23604114

2014

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE With the discovery of hypoxia inducible factor-1 (HIF-1), which is widely overexpressed across a broad range of cancers, modern molecular tools have allowed us to put together the pattern of events that might explain the metabolic differences between tumor and normal cells. 12558074

2003