Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GenomicAlterations CGI

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 CausalMutation CGI

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Our results demonstrate that the HIF-1/HRE system of gene regulation is active in hypoxic tumor cells and show the potential of exploiting tumor-specific conditions for the targeted expression of diagnostic or therapeutic genes in cancer therapy. 9142119

1997

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Recent studies have provided evidence that important pathophysiological responses to hypoxia in pulmonary hypertension, myocardial ischemia, and cancer are mediated by HIF-1. 10849654

2000

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE To demonstrate how pancreatic cancer cells adapt themselves to hypoxia and nutrient deprivation, we investigated the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and HIF-1-inducible genes in human pancreatic cancer cell lines in comparison with other cancer cell lines. 11522653

2001

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE VHL acts in a ubiquitin ligase complex regulating hypoxia-inducible factor-1 (HIF-1), but the link between this function and cancer development is unclear. 12124175

2002

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Its functional requirement for HIF-1 activity was also demonstrated in several different cancer cell lines, but AMPK activation alone was not sufficient to stimulate the HIF-1 transcriptional activity. 12900407

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE With the discovery of hypoxia inducible factor-1 (HIF-1), which is widely overexpressed across a broad range of cancers, modern molecular tools have allowed us to put together the pattern of events that might explain the metabolic differences between tumor and normal cells. 12558074

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Thus, our study has shown that HIF-1 regulated genes have potential for future use as predictors of the malignant changes mediated by hypoxia, and warrant further investigation as indicators of response to cancer therapy. 12532423

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE HIF-1 is also important in disease, for example in cancer where it is involved in angiogenesis. 12195866

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Targeting HIF-1 for cancer therapy. 13130303

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. 12507560

2003

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE HIF-1 activates genes that allow the cancer cell to survive and grow in the hostile hypoxic tumor environment. 15141023

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is regulated by the hypoxia-inducible factor 1 (HIF1) pathway and is implicated in tumor progression and patient survival in many types of cancer. 15086970

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE They also suggest the existence of novel mechanisms of telomerase activation in cancers, and have implications for the molecular basis of hypoxia-induced tumor progression and HIF-1-based cancer gene therapy. 15048086

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Therefore, it is apparent that the inhibition of HIF-1 activity may be a strategy for treating cancer. 15313402

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE These results provide a compelling rationale for testing topotecan in clinical trials to target HIF-1 in cancer patients. 15466170

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Thus, the correlated regulation of DNA-PK with HIF-1 could contribute to therapy resistance in hypoxic tumor cells, and it provides new evidence for developing therapeutic strategies enhancing the efficacy of cancer therapy in hypoxic tumor cells. 15272235

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE The pharmacological manipulation of HIF-1 has marked effects on tumour growth, and it could prove to be an important target for drug therapy, both in cancer and in other hypoxia-dependent disease states. 15135470

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE An understanding of underlying mechanisms involved in the activation of HIF-1 in response to both hypoxic stress and oncogenic signals has important implications for how these processes may become deregulated in human cancer. 14988927

2004

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Elevated levels of HIF-1alpha, a subunit of HIF-1, are noted in various malignant tumors, but it is unclear whether this is so in esophageal carcinoma. 15771621

2005

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Ero1-L alpha plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer. 15592500

2005

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Since increased HIF-1 expression correlates with advanced disease stage, increased angiogenesis and poor prognosis, HIF-1 and its signaling pathway have become targets for cancer chemotherapy. 16596228

2006

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Hypoxia, shortage in oxygen, greatly influences cellular phenotypes by altering the expression of specific genes, and is an important contributor to intra- and inter-tumor cell diversity as revealed by the pronounced but non-uniform expression of hypoxia-driven genes in solid tumors (reviewed in [Semenza GL.Targeting HIF-1 for cancer therapy. 16144692

2006

Entrez Id: 29072
Gene Symbol: SETD2
SETD2
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Hypoxia-inducible factor-1 (HIF-1) is a key regulator of genes crucial to many aspects of cancer biology. 16682012

2006