Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia. 24962835

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Ongoing research has identified a region of the HTR2A promoter that has been associated with a number of medical outcomes in adults and infants, including bipolar disorder, schizophrenia, chronic fatigue syndrome, borderline personality disorder, suicidality, and neurobehavioral outcomes. 25043477

2014

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.© 2013 Wiley Periodicals, Inc. 23404241

2013

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Logistic regression analysis showed a significant effect of the ALDH2 and the 5-HT2A-A1438G polymorphisms, and a significant interaction effect for the A/G genotypes of the 5-HT2A-A1438G polymorphism and the ALDH2*1*1 genotypes (p=0.004) discriminated between bipolar-I patients and controls without bipolar disorder. 22564712

2012

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker PSYGENET Furthermore, epigenetic down-regulation of HTR2A was associated with early age of disease onset in SCZ and BD. 21550210

2011

Entrez Id: 3356
Gene Symbol: HTR2A
HTR2A
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.800 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.740 Biomarker PSYGENET Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154

2011

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.740 Biomarker PSYGENET Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001). 21714070

2011

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.740 Biomarker PSYGENET These genes include GRM7, previously associated to major depression disorder and bipolar disorder, SLC6A13, in anxiety disorders, and S100B, SSTR5 and COMT in schizophrenia. 20398908

2010

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.740 Biomarker PSYGENET Fine-mapping analyses of 21q22 have previously identified transient receptor potential gene melastatin 2 (TRPM2), which is 2 Mb upstream of S100B, as a possible BPAD susceptibility gene at 21q22. 17525977

2007

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.740 Biomarker CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148

2006

Entrez Id: 6285
Gene Symbol: S100B
S100B
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.740 Biomarker CTD_human Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania. 15581912

2004

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756

2019

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756

2019

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function. 25744938

2015

Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Genotyping for COMT polymorphisms was carried out by DNA direct sequencing in 112 patients (54 MDD and 58 BD) and 58 healthy subjects. 25766270

2015

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET This study provides new insights on the neurogenetic correlates of allelic variation at different genome-wide supported BD-risk associated ANK3 loci that support their involvement in BD and highlight the modulatory influence of increased background genetic risk for BD. 25711502

2015

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Our findings implicate abnormal perigenual and hippocampal activation as a promising intermediate phenotype for psychiatric disease and suggest a pathophysiologic mechanism conferred by a CACNA1C variant being implicated in risk for symptom dimensions shared among bipolar disorder, major depression, and schizophrenia. 24411473

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET The variants at ANK3 and CACNA1C previously known to be associated with BP were not in linkage disequilibrium with either of the two variants that we identified and these are therefore independent of the previous haplotypes implicated by genome-wide association. 24716743

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. 25304227

2014

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. 25304227

2014

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET In a sample of 49 patients with bipolar disorder and 633 healthy subjects, we examined possible effects of 2 risk variants within ANK3, rs10994336 and rs10761482, on 7 neurocognitive domains. 24655771

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET In treatment of BD with calcium channel blocking drugs, we would predict better response in patients without the risk allele, because they have increased CACNA1C expression. 23979604

2014

Entrez Id: 288
Gene Symbol: ANK3
ANK3
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET The gene ANK3 is implicated in bipolar disorder and schizophrenia. 24016415

2014

Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.700 Biomarker PSYGENET The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. 25290268

2014