Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE COX-2 level is significantly lower in nevi than in melanomas, increases gradually with progression of these malignant cancers and reaches the highest values in metastases. 31675116

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Co-Altered Ras/B-raf and TP53 is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Metastatic Colorectal Cancer Patients. 31719050

2020

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes, such as cancer metastasis. 31820313

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) are involved in the breakdown of extracellular matrix in normal physiological processes as well as in disease processes, such as cancer metastasis. 31820313

2020

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In ATAT for the group of patients with distant metastasis (M1) the superoxide generation rate, MMP-2, 9 activities are about 2 times higher (p < 0.05) than in the subgroup without distant metastases (M0). 31711773

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Mechanistically, we found that the phosphatidylinositol 3-kinase-AKT signal pathway and its downstream effectors, such as tissue inhibitor of metalloproteinases 1 and matrix metallopeptidase 9, were required for MUC13-mediated tumor metastasis of iCCA. 31837357

2020

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE BRAF mutant and HER-2 positive mCRC will soon be provided with approved targeted treatments and check-point inhibitors demonstrated effectiveness in microsatellite instability (MSI) - high mCRC. 31786838

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Importantly, this biosensor reports back on molecular signatures characteristic to metastatic tumors and associated with poor prognosis - MMP9 protease overexpression. 31747099

2020

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE Immunohistochemical expression was found for MMP-14 in all primary tumors as well as in all metastases and for MMP-2 expression in most of the samples. 30741846

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Immunohistochemistry was performed for AR, ERβ and p53 on 125 primary TNBCs with known metastasis and correlated with clinicopathological parameters and outcome. 31563883

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE KRAS and GNAS are frequently altered in low-grade AMTs, while TP53 is frequently altered in high-grade AMTs, with no apparent change in expression between primary and metastatic tumors. 31583543

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE It has been recently shown that mutant p53 proteins mediate metabolic changes thereby promoting cancer development and metastases. 31112799

2020

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In multivariate analysis, histologic grade 3 (p = 0.014), presence of extracranial metastasis (p < 0.001), the number of BM (>4; p = 0.002), hormone receptor negativity (p = 0.005), HER2-negativity (p = 0.003), and shorter time interval (<30 months) between BC and BM diagnosis (p = 0.007) were associated with inferior OS. 31677532

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Migration and invasion potential of SGC7901 cells, EMT biomarkers and MMP-9 in SGC7901 cells, and metastasis of gastric cancer to lungs in mice were coordinately inhibited by DAPT and LY294002. 31732769

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE The elevated sequential activation of AR/PIP5K1α/AKT/MMP9/VEGF signaling axis contributed to increased invasiveness and growth of metastatic tumors. 31381135

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 GeneticVariation BEFREE Mutations in p53 have been implicated in the pathogenesis of primary prostate cancer (PCa), and are often detected in recurrent and metastatic disease. 31471556

2020

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE High KANK1 protein expression was correlated with smaller tumour size and HER2 negativity, and better outcome in terms of longer breast cancer-specific survival [p = 0.013, HR 0.7, 95% CI 0.536-0.893] and time to distant metastasis [p = 0.033, HR 0.65, 95% CI 0.51-0.819]. 31679074

2020

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In the multivariate analysis, significant independent predictors in nonSLN metastasis development were found to be HER2 positivity, PNI, mSLN diameter ≥10,5 mm and ENE. 31519397

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Knockdown of miR-574-5p induced an up-regulation of E-cadherin and down-regulation of cyclinD1, N-cadherin, matrix metallopeptidase 9 (MMP-9), and β-catenin in cervical cancer cells Moreover, QKI was verified as a target of miR-574-5p and involved in regulation of miR-574-5p-induced cervical cancer cell progression and metastasis. miR-574-5p functions to be oncogenic in cervical cancer, and its inhibition suppresses cervical cancer progression and metastasis as well as enhances chemosensitivity by targeting QKI. 31786621

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Ado-trastuzumab emtansine (T-DM1/Kadcyla<sup>®</sup>;Genentech) is an antibody-drug conjugate used in the treatment of human epidermal growth factor receptor-2-positive metastasized breast cancer. 30820718

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE In addition, the knockdown of p53 in K1 and TPC-1 cells partially reversed the inhibitory effect of LINC00673 deficiency on the proliferation and metastasis of PTC cells. 30915752

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Impact Statement Cancer invasion and metastasis have been shown to be driven by matrix metalloproteinase 9 (MMP9), whose expression mechanism is not clarified yet. 30734664

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 AlteredExpression BEFREE MPPa-PDT downregulated the expression of MMP2 and MMP9, which are responsible for the initiation of metastasis. 31783821

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Ectopic expression of ZCCHC10 in lung cancer cells harboring wild-type p53 dramatically suppresses cell proliferation, colony formation, migration, invasion and cisplatin resistance in vitro, as well as tumor growth and metastasis in vivo. 31138778

2019

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.600 Biomarker BEFREE Patients with HER2 amplification showed shorter median times from disease discovery to LN metastasis (HER2 amplification vs HER2 non-amplification; 15.6 vs. 10.0 months; P=0.50) and from LN dissection to disease progression (HER2 amplification vs. HER2 non-amplification, 16.2 vs. 13.6 months; P=0.11). 30854041

2019