Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE The use of biologics targeted to the human epidermal growth factor receptor 2 (HER2) protein is the latest addition to the armamentarium used to fight advanced gastric or gastro-oesophageal junction adenocarcinoma. 29439009

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE Overexpression of HER2 protein and amplification of the <i>ERBB2</i> gene has been observed in various adenocarcinomas, providing a therapeutic target that can be used to extend the survival of a select cohort of patients. 28784859

2018

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE The current study was a multicenter, single-arm, phase 2 study performed to investigate the feasibility and efficacy of bevacizumab combined with docetaxel, oxaliplatin, and capecitabine (B-DOC) in patients with advanced human epidermal growth factor receptor 2 (HER2)-negative, previously untreated, gastric or gastroesophageal adenocarcinoma. 26970343

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications. 27530622

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE Comparable clinical outcomes in patients with HER2-mutant and EGFR-mutant lung adenocarcinomas. 28063177

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. 27841667

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma. 27517839

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Digital Image Analysis of HER2 Immunostained Gastric and Gastroesophageal Junction Adenocarcinomas. 27801737

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium. 28743157

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE Two uterine serous adenocarcinomas and one grade 3 endometrioid adenocarcinoma showing HER2 positivity were treated with trastuzumab and paclitaxel. 27798902

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology. 28077399

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE We identified 15 cases (0.18%) of HER2 TMD mutations (HER2<sup>V659E/D</sup>, HER2<sup>G660D</sup>) through CGP of 8551 lung adenocarcinomas. 27903463

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE Tumor specimens from 175 patients with lung adenocarcinomas and no prior targeted therapy were evaluated for the presence of HER2 amplification and mutation and HER2 protein overexpression. 26723242

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations are observed in mucinous adenocarcinoma and adenocarcinoma with micropapillary features. 27403614

2017

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Considering the large amount of drugs that target ERBB2 (HER2) and ERBB3 (HER3), and which are currently in different stages of clinical development, detecting and targeting NRG1 fusions in invasive mucinous lung adenocarcinomas may represent a therapeutic opportunity for this aggressive disease. 25501131

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Gastric and gastroesophageal junction (GEJ) adenocarcinomas have been shown to display significant HER2 genetic heterogeneity (GH). 25611242

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE In contrast this amplicon was absent in ER+ (0/8) and HER2+ (0/15) breast tumors, and in pancreatic ductal adenocarcinomas (0/150). 26317899

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE HER2 expression in oesophageal carcinoma and Barrett's oesophagus associated adenocarcinoma: An Australian study. 26422587

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Human epidermal growth factor receptor 2 testing in gastric and gastroesophageal junction adenocarcinomas: role of the gastroenterologist. 25805465

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Mutations or amplifications of ERBB2 were more frequent in ACUPs (13 [10%]) than in non-ACUPs (3 [4%]). 26182302

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 AlteredExpression BEFREE The HER2 (official name ERBB2) gene encodes a membrane receptor in the epidermal growth factor receptor family amplified and overexpressed in adenocarcinoma. 26320869

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Addition of lapatinib to CapeOx did not increase OS in patients with HER2-amplified gastroesophageal adenocarcinoma. 26628478

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE HER2 mutations have been identified as oncogenic drivers in lung cancers and are found in 1-2% of lung adenocarcinomas. 26598547

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 Biomarker BEFREE Currently, predictive biomarkers for gastrointestinal cancers include Her2 overexpression or amplification (gastroesophageal adenocarcinoma), c-Kit overexpression (gastrointestinal stromal tumors) and RAS wild-type (colorectal cancer). 25924988

2016

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.400 GeneticVariation BEFREE The aim of this study was to compare HER2 amplification, as determined by the HER2 copy number (CN) and the HER2/CEP17 ratio, with protein expression in gastric and gastro-oesophageal junction (G/GOJ) adenocarcinoma.HER2 immunohistochemistry (IHC) and silver in situ hybridisation (SISH) were performed in 185 cases. 24614718

2015