Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE We show that long-read sequencing with a single Oxford Nanopore Technologies PromethION flow cell per individual achieves 30× human genome coverage and enables accurate assessment of tandem repeats including the 10,000-bp Alzheimer's disease-associated ABCA7 VNTR. 31727106

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Massive parallel sequencing recently allowed the identification of three genes carrying a higher burden of rare, protein-truncating and missense predicted damaging variants in Alzheimer disease (AD) cases as compared to controls: TREM2, SORL1, and ABCA7. 30911827

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Several genes associated with AD risk-most notably, the ε4 allele of the apolipoprotein E (APOE) gene and several mutations in the ATP-binding cassette transporter A7 (ABCA7) gene-are linked to altered lipid metabolism, especially in AAs. 30747415

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD. 31024289

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Besides associations with disease status, these genetic and epigenetic ABCA7 markers also showed significant correlations with AD endophenotypes; in particular amyloid deposition and brain morphology. 30903345

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE While we cannot identify the exact mechanism underlying the observed alterations in EC structure and network function, considering the relevance of Aβ in ABCA7 related AD pathogenesis, the results of our study may reflect the synergistic reinforcement between amyloid and tau pathology in the EC, which significantly increases tau-induced neuronal loss and accelerates synaptic alterations. 30318785

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Here, we review the effects of the two largest genetic risk factors for AD in African Americans: Apolipoprotein E (APOE) and ABCA7. 31749691

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Our case-control study (416 AD patients and 302 controls) provides further data on the rs3752246 polymorphism in AD in the Hungarian population that has not been investigated so far regarding the ABCA7 gene variants. 30717989

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Clarifying the effect of APOE-ABCA7 interactions on the default mode network and memory is critical to exploring the complex pathogenesis of Alzheimer's disease and refining a potential therapy. 31831047

2019

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE In conclusion, ABCA7 genetic variants, especially the LOF mutations, were significantly associated with the risk of AD. 29782324

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 AlteredExpression BEFREE We identified 789 and 998 DEGs common to both blood and brain of AD and MCI subjects respectively, over 77% of which had the same regulation directions across tissues and disease status, including the known ABCA7, and the novel TYK2 and TCIRG1. 30478411

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Our findings supported that ABCA7 modified AD risk by altering Aβ deposition rather than tau pathology. 30596067

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Our study in murine BBB model highlighted a putative new role for ABCA7 in AD via the protein's involvement in cholesterol metabolism and amyloid clearance at the BBB. 30010117

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer's Disease. 29504051

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE ABCA7 and Pathogenic Pathways of Alzheimer's Disease. 29401741

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Our findings underline the importance of studying repetitive DNA in complex disorders and expand the contribution of genetic and transcript variation in ABCA7 to AD. 29589097

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 AlteredExpression BEFREE M344 increases the expression of AD-relevant genes: BDNF, α-secretase (ADAM10), MINT2, FE65, REST, SIRT1, BIN1, and ABCA7, among others. 29073110

2017

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE In conclusion, our findings showed that ABCA7 had obvious anti-Aβ effect and appeared to improve cognitive function of AD mice. 28124230

2017

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE ATP-binding cassette transporter A7 (ABCA7) gene, regulating the transport of cholesterol, has been recently identified as a susceptible gene of AD by several large genome-wide association studies. 29111006

2017

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE In conclusion, this meta-analysis suggested that ABCA7 rs3764650 polymorphism is significantly associated with AD risk. 29441941

2017

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Targeted sequencing of ABCA7 identifies splicing, stop-gain and intronic risk variants for Alzheimer disease. 28400126

2017

Entrez Id: 10347
Gene Symbol: ABCA7
ABCA7
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE We investigated the association of Alzheimer's disease (AD)-related rare variants APP A673T and ABCA7 rs200538373-C with the levels of β-amyloid (Aβ) and parameters of metabolic and cardiovascular health in a population-based cohort of healthy middle-aged and elderly men. 28556232

2017