Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker BEFREE The first step of HIV infection involves the interaction of the gp120 envelope glycoprotein to its receptor CD4, mainly expressed on CD4+ T cells. 28346521

2017

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 GeneticVariation BEFREE Samples were obtained from a cohort of 17 patients with early HIV infection (<6 months after infection) who initiated ART, and the C2V5 region of the HIV-1 envelope (env) gene was amplified via single genome amplification (SGA) to determine the peripheral plasma HIV quasispecies. 27791274

2017

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker BEFREE Thus, the gp41 HR1 region contributes to the association with gp120 and regulates Env transitions from the unliganded state to downstream conformations.<b>IMPORTANCE</b> The development of an efficient vaccine able to prevent HIV infection is a worldwide priority. 28003492

2017

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 GeneticVariation BEFREE An important step in human immunodeficiency virus infection involves the interaction between the viral envelope glycoprotein gp120 and the human host cell surface receptor CD4. 22117536

2012

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker BEFREE Direct signaling by envelope glycoprotein killed CD4-negative γδ T cells and reproduced a defect observed in all patients with HIV disease. 21926353

2011

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker BEFREE Short interfering RNA knockdown of endogenous UNG2 in primary cells showed that UNG2 is required for R5 but not X4 HIV infection and that this requirement is bypassed when HIV enters the target cell via vesicular stomatitis virus envelope-glycoprotein-mediated endocytosis. 20371602

2010

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 GeneticVariation BEFREE We compared the pattern of evolution of the HIV-1 env gene between individuals with recent HIV infection whose virus exhibited either a low or a high rate of escape from neutralizing antibody responses. 16339909

2005

Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
CUI: C0019693
Disease: HIV Infections
HIV Infections
0.080 Biomarker BEFREE In addition, the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha, MIP1beta, and RANTES, natural ligands of CXCR4 and CCR5, respectively, are potent soluble inhibitors of HIV infection by blocking the binding between the viral envelope glycoprotein gp120 and the coreceptors. 10820198

2000