Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.060 Biomarker BEFREE Native vs. PEG-ASP administered according to availability in each center were prospectively evaluated in adults with high-risk ALL. 29165013

2018

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.060 Biomarker BEFREE The aim of the present study was to investigate the growth inhibition effects of GA in combination with asparaginase (ASP), as a component of combination chemotherapy, in a lymphoblastic leukemia cell line. 29217160

2017

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.060 Biomarker BEFREE Asparaginase (ASP) is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL). 28440015

2017

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.060 AlteredExpression BEFREE ASP and ATIII activity was measured in 76 children with ALL treated according to the ALL IC BFM 2002 protocol. 28060110

2017

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.060 GeneticVariation BEFREE Patients with GRIA1 rs4958351 AA/AG genotype showed significantly reduced risk to ASP hypersensitivity compared to patients with GG genotype in the T-cell ALL subgroup (OR = 0.05 (0.01-0.26); p = 4.70E-04), while no such association was found in pre-B-cell ALL. 26457809

2015

Entrez Id: 29974
Gene Symbol: A1CF
A1CF
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.060 GeneticVariation BEFREE Thrombotic events (TEs) are serious secondary complications in children with acute lymphoblastic leukemia (ALL) who receive L-asparaginase (ASP) therapy; however, the prevalence of TEs has not been established. 12518376

2003