Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Further, meta-analysis revealed significant association of IL-1β rs1143627: T > C (p = 0.026; OR = 4.165; 95% CI 1.18-14.65) and rs16944: C > T (p = 0.01; OR = 5.49; 95% CI 1.48-20.37) in presence of H. pylori with gastric cancer in Asian population though no significant difference (p > 0.05) was found when compared to absence of H. pylori . 30094865

2018

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 AlteredExpression BEFREE IFN-γ and IL-10 levels were significantly higher in early (I/II) and late stage (III/IV) gastric cancer; IL-1β and IL-8 were higher and MCP-1 was lower only in late stage (IV) patients. 28558708

2017

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The pro-inflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors, and polymorphisms in the IL-1 gene cluster resulting in increased IL-1β production have been associated with increased risk for gastric cancer. 27460807

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Subgroup analysis showed a significant correlation between IL-1β-511C/T polymorphism and susceptibility to gastric cancer in residents of southern China and in patients with intestinal-type gastric cancer, but not in residents of northern China or in patients with diffuse gastric cancer. 27215350

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Furthermore, H. pylori infection has a synergistic effect on the development of GC with IL-1β gene polymorphisms, and the highest prevalence of severe gastric abnormalities are found in patients with both host and bacterial high-risk genotypes (cagA(+)/vacAs1(+)/IL-1β-511T). 27076787

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE Disruption of the HNF4α/IL-1R1/IL-1β/NF-κB circuit during Hp infection maybe an effective means of preventing the associated GC. 26870992

2016

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Based on subgroup analysis, H. pylori infection and genotype analysis using PCR-RFLP methods increase the association between IL-1β-511 T allele carrier and risk of stomach cancer. 25258120

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations. 24557417

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE These results suggested that SNPs in the IL-1 family genes play important roles in the development of GC and the IL-1F5 might be the target gene of miR-197, and miR-197 might negatively regulate its expression. 26632693

2015

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 AlteredExpression BEFREE IL-1β stimulated uPA expression through ERK and NF-κB in gastric cancer, which may therefore be promising targets for gastric cancer therapy. 24626561

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The proinflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors and polymorphisms in the IL-1 gene cluster leading to increased IL-1β production have been associated with increased risk for gastric cancer. 25172489

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 PosttranslationalModification BEFREE IL-1β may be an important mediator for H. pylori induced gene methylation during GC development. 24023501

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains. 22414649

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Our results demonstrated that the IL-1β -511 C/C and IL-1β -511 C/T alleles were associated with chronic gastritis in H. pylori-positive patients (P = 0.04 and P = 0.05, respectively) and the IL-1β -511 C/C genotype was associated with GC (P = 0.03). 22714811

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains. 22414649

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05). 21649724

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 AlteredExpression BEFREE Functionally, 2 RUNX3 isoforms may contribute differentially to intestinal-type gastric cancer susceptibility, at least in part through regulating NF-κB activity and IL1B expression. 21523770

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE So far, a number of association studies have focused on the effect of polymorphisms in IL-1β and TNF-α genes on the susceptibility to gastric cancer (GC). 21246243

2011

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE These findings suggest that the IL1B-511T/T allele is associated with enhanced hypermethylation of multiple CpG island loci, which might contribute to an increase in the risk for gastric cancer in individuals with H. pylori infection and IL1B-511T/T allele. 20405297

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls. 20332462

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden. 19031173

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human The effects of interleukin-1beta (IL-1beta) and epigenetic mechanisms on 15-PGDH regulation were assessed in gastric cancer cell lines. 19584167

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians. 19861615

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Multivariate regression analysis showed that cagE, babA2, and IL-1RN-1/2 genotypes were independent predictors of GC, but when patients with benign disorders were grouped together (NUD + DU) and compared with patients with GC, regression analysis disclosed that babA2 (P = 0.000) and IL-1B-31 gene polymorphisms (CC or CT) (P = 0.01) were the only independent markers of GC. 18807132

2008

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE It has been reported that interleukin-1beta (IL-1B) genes play a crucial role in the genetic predisposition to gastric cancer although there is no information about their role in different subtypes of gastric cancer. 18688641

2008