Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE In an analysis of data from almost 4000 carriers of Lynch syndrome-associated mutations, we found history of gastric cancer to be independently associated with male sex, older age, mutations in MLH1 or MSH2, and with having a first-degree relative with gastric cancer. 31319185

2020

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE TP53 mutations were highly recurrent (11/14; 79%) in MLH1-positive miGCs and were detected even in two microscopic lesions measuring 1 and 3 mm, respectively. 30474112

2019

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology. 31207149

2019

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Microsatellite instability (MSI) marker MLH1 and Epstein-Barr virus (EBV) marker EBER were examined on 30 cases of Chinese GC by immunohistochemistry and <i>in situ</i> hybridization. 30422018

2019

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE One hundred and sixty-five GCs were classified into five subgroups using immunohistochemistry (IHC) and in situ hybridization (ISH) methods, based on a panel of seven markers (MLH1, PMS2, MSH2, MSH6, E-cadherin, P53, and Epstein-Barr virus mRNA). 31372044

2019

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE The pooled sensitivity, specificity, and AUC of MLH1 promoter methylation in GC with MSI vs. GC with microsatellite stability (MSS) samples were 0.64, 0.96, and 0.90, respectively. 29334683

2018

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Association Between hMLH1 Promoter Methylation and Risk of Gastric Cancer: A Meta-Analysis. 29719511

2018

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Further study could be conducted to verify the impact of MLH1 methylation on GC prognosis. 29896277

2018

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE H3K36me3 and H3K4me2 levels were lower in hMLH1 exon 10-11 and exon 16-17 regions in gastric cancer lines when compared with GES-1. 28381181

2017

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE The MLH1 rs1800734 polymorphism is associated with GC risk. 26724419

2016

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE CIMP and/or MLH1 methylation status may have a potential to be prognostic biomarkers for patients with gastric cancer. 26121593

2015

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Mismatch repair was affected by a mutation of MLH1 in 1 GC and by aberrant methylation of MLH1 in 2 GCs. 24510342

2015

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently detected in the intestinal phenotype of GC, whereas CDH1 gene mutation, microsatellite instability and DNA hypermethylation of MLH1 are common events in the gastric phenotype of GC. 26033320

2015

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE MLH1 methylation was related to oxaliplatin resistance in gastric cancer patients. 24748501

2015

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 AlteredExpression BEFREE The DNA methylation occurred in promoter regions of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer. 26823831

2015

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE Aberrant DNA methylation of MGMT and hMLH1 genes in prediction of gastric cancer. 24938706

2014

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE Aberrant hypermethylation of P16, MGMT, hMLH1 and hMLH2 could be predictive of gastric cancer. 23803092

2013

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Furthermore, some of the known clinicopathologic features of MSI+ GC, including older age of onset, ulcerofungating gross morphology, and antral location, are not typical of MSI+ GC without MLH1 methylation. 23266441

2013

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE This study revealed that hMLH1 hypermethylation is strongly associated with GC and suggested roles for epigenetic changes in stomach cancer causation in the Kashmir valley. 23098428

2012

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied. 22936446

2012

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16(INK4a) in suspected cases of hereditary gastric cancer (GC). 22228973

2012

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 PosttranslationalModification BEFREE These data imply that relatives of CRC cases with MLH1 methylation may be at increased risk of CRC and stomach cancer and possibly ovarian and liver cancer, suggesting that there may be a heritable factor for CRC and other cancers associated with MLH1 methylation in non-Lynch syndrome CRCs. 22144422

2012

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Compared with the MLH1 2101CC genotype, the 2101CA genotype was associated with a risk of gastric cancer (OR = 8.42, 95% CI = 1.04-68.06) in males. 22136435

2011

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 GeneticVariation BEFREE Hereditary non-polyposis colorectal cancer is the most common known genetic syndrome that predisposes to various types of cancer including gastric cancer and occures mainly due to pathogenic germline mutations in DNA mismatch repair (MMR) genes, such as MLH1, MSH2 and MSH6. 21136174

2011

Entrez Id: 4292
Gene Symbol: MLH1
MLH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.400 Biomarker BEFREE We verified that the frequency of MSI was similar in familial and sporadic GC settings, demonstrating that this molecular phenotype is not a hallmark of familial GC in contrast to what is verified in HNPCC. 20533283

2011