Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations. 31077828

2020

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer. 30168144

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE The poorly cohesive histology/CDH1-mutant GC subgroup showed the worst survival (p < 0.001). 30801717

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE The cumulative incidence of gastric cancer for individuals with pathogenic variants in CDH1 is significantly lower than previously described. 31246251

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer. 30642281

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 PosttranslationalModification BEFREE CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients. 30989488

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 AlteredExpression BEFREE Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC. 30963578

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Our results demonstrate that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori. 29589180

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology. 31207149

2019

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 AlteredExpression BEFREE CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa. 29443099

2018

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE We identified a new truncating germline mutation (p.Asp538Thrfs*19) in exon 11 of the CDH1 gene in a 41-year-old male with a diffuse gastric cancer. 29131691

2018

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 AlteredExpression BEFREE The results revealed that CDH1, cyclooxygenase-2 and matrix metalloproteinase genes had significantly higher expression levels, whereas the expression levels of dermatopontin and transforming growth factor β receptor 2 were decreased in GC samples. 29434905

2018

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC). 28993866

2018

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy. 27759617

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. 28024868

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 AlteredExpression BEFREE For the first time, we evaluated by digital PCR the expression of CDH1 and CDH1a transcripts in cancer and normal tissue samples from 32 patients with intestinal-type gastric cancer. 27861150

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 PosttranslationalModification BEFREE In addition, methylation of the CDH1 gene in AM may be a surrogate of GC. 29042646

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 Biomarker BEFREE It is implied that TRERNA1/CDH1 is a new potential target for GC therapy. 28918030

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Female predominance in early-onset gastric cancer may be related to relatively high rates of somatic CDH1 and TGFBR1 mutations in this population. 28522256

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE The <i>CDH1</i> gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. 29295527

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results. 27706737

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family. 27880784

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE Germline E-cadherin/CDH1 mutations have been identified in families with an autosomal dominant inherited predisposition to diffuse gastric cancer. 27899187

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE This study was aimed to analyse the hypermethylation status of the E-Cadherin (CDH1) gene promoter in GCs in the ethnic Kashmiri population. 27356686

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.800 GeneticVariation BEFREE All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer. 26072394

2015