Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Challenges related to defining the role of progesterone in breast physiology and neoplasia include: complex interactions with estrogens and other hormones (e.g., androgens, prolactin, etc.), accounting for timing of blood collections for hormone measurements among cycling women, and limitations of assays to measure progesterone metabolites in blood and progesterone receptor isotypes (PRs) in tissues. 31512725

2020

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE According to a univariate analysis, fine pleomorphic/fine linear or linear-branching calcification morphology on mammography, parallel orientation on ultrasound, intratumoral high signal intensity on T2-weighted magnetic resonance imaging, progesterone receptor negativity, and high levels of tumor-infiltrating lymphocytes were associated with pCR. 31519449

2020

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Among these, age, size of the primary breast tumor, tumor localization and multifocality/multicentricity status, preoperative serum Neutrophil/Lymphocyte rate (NLR), c-erbB2/HER2-neu status, Estrogen Receptor (ER) and Progesterone Receptor (PR) status, primary tumor proliferation index (Ki-67), histopathological grade, molecular subtypes, histopathological subtypes, nipple/areola infiltration, Lymphatic Invasion (LI), Vascular Invasion (VI), Perineural Invasion (PNI), number of metastatic SLN m(SLN), mSLN diameter, SLN Extranodal Extension (ENE) status, and number of metastatic nonSLNs were recorded. 31519397

2020

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Expression patterns of the estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) and Ki67 were compared in primary tumors and bone or bone marrow lesions. 30793198

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE We found that k3, Ki and MRFDG were significantly higher in higher grade (p = 0.0246, 0.0089 and 0.0076, respectively), progesterone-receptor negative (p = 0.0344, 0.0217 and 0.0132) and highly-proliferating (p = 0.0414, 0.0193 and 0.0271) tumors as well as in triple-negative and hormone-receptor negative/HER2-positive subtypes (p = 0.0310, 0.0280 and 0.0186). 30941738

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The purpose in this study was to compare the discordance in estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) between primary and recurrent/metastatic lesions (RML) and also to evaluate the prognostic significance of change in tumor phenotype on survival in patients with metastatic BC. 28534357

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE We suggest, that a high concentration of heparanase next to tumour size and oestrogen and progesterone receptor expression may serve as an indicator of a more an aggressive character of tumour cells and a shorter survival rate. 31566192

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Nulliparous patients tended to have receptor-positive [estrogen receptor (ER)+ or progesterone receptor (PR)+] tumors. 30993643

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Progesterone receptor-negative status, larger tumor size, and high tumor grade were significantly associated with high-risk RS. 30595493

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Influence of ODXRS on staging is limited to T2N0 tumors that are either GR 3 and strongly ER<sup>+</sup> and PR<sup>+</sup> or GR 1-2 and ER<sup>+</sup>/PR-. 30509870

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Kaplan-Meier analysis indicated that patients presenting with reduced ITM2A expression exhibited poor overall survival, and expression significantly correlated with age, progesterone receptor status, TNM classification and tumor stage. 31438969

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Immunohistochemistry (IHC) is widely used to analyze estrogen receptor 1 (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) that can help classify the tumor to guide the medical treatment. 31010819

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Tumours with the infiltrating pattern were associated with high FIGO grade (P = 0.002), reduced ER and PR, and CD44 expression (P = 0.014, 0.026, and 0.030, respectively); those with a MELF pattern showed LN metastasis (P < 0.001), lymphovascular invasion (P = 0.011), and reduced ER, CD44, and CD133 expression (P = 0.036, 0.006, and 0.016, respectively). 28990139

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In G2 tumors, MCpt correlated with ER (p=0.015) and PR (p=0.038) while in G3 tumors ER correlated with both MCit (p=0.009) and MCpt (p=0.000487) tumors. 31028192

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE <b>Results:</b> Older age, higher grade tumor and progesterone receptor (PR)-negative disease were independent predictors of high-risk RS stratification. 31234641

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE We found that the tumor type that was positive for only the progesterone receptor and negative for both the estrogen receptor and human epidermal growth factor receptor-2 (1.3% of all cases) had a proliferative activity that was consistently much higher than those of the other luminal subtypes. 30916428

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE ER and PR negativity were determined when <1% tumor nuclei were stained. 30479097

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE <b>Principal conclusions:</b> Tumor-associated MUC1 is a very important biomarker for breast cancer next to the traditional markers estrogen receptor (ER), progesterone receptor (PR) and HER/2-neu. 31588183

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The associations between mammographic casting-type calcification and other clinicopathological factors, including tumor size, node status, grade, progesterone receptor (PR) status, estrogen receptor (ER) status, and human epidermal growth factor receptor 2 (HER2) status, were analyzed. 31332233

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Increased pretreatment AAPR level was related to age at diagnosis (≥60 years vs <60 years, <i>P</i>=0.000), tumor size (T≤2 cm vs T>2 cm, <i>P</i>=0.034), estrogen receptor (positive vs negative, <i>P</i>=0.022), progesterone receptor (positive vs negative, <i>P</i>=0.025), carcino-embryonic antigen (abnormal vs normal, <i>P</i>=0.016), surgery (lumpectomy vs mastectomy, <i>P</i>=0.002), chemotherapy (yes vs no, <i>P</i>=0.004), radiotherapy (yes vs no, <i>P</i>=0.013), endocrine therapy (yes vs no, <i>P</i>=0.027) but not with lymph node involvement, HER-2 status or CA-153. 31213902

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE <i>PIK3CA</i> mutations were associated with the estrogen receptor-positive/progesterone receptor-positive (ER<sup>+</sup>/PR<sup>+</sup>) group of tumors in contrast to the ER<sup>-</sup>/PR<sup>-</sup> group (P=0.021). 31404155

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 PosttranslationalModification BEFREE ESR1/PGR frequently undergoes de novo methylation and loss expression in a wide variety of tumors, including breast, colon, lung, and brain tumors. 30614867

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE FN cases were more frequently estrogen receptor positive (P<0.001), progesterone receptor positive (P=0.001), human epidermal growth factor receptor-2 negative (P=0.009) and histologic grade 1 (P=0.015), which most likely reflects the lower rates of pathologic complete response in these tumors. 31219817

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The discordance rates of estrogen receptor (ER), progesterone receptor (PR), and HER2 protein expression were 18.2% (95% confidence interval (CI): 7.9-28.8%), 36.4% (95% CI: 23.7-49.1%), and 8.2% (95% CI: 0.1-16.3%), respectively, between the primary tumor and metastatic lesion. 31620243

2019

Entrez Id: 5241
Gene Symbol: PGR
PGR
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE There were statistically significant differences between different IHC intrinsic subtypes regarding tumor size (p=0.001), estrogen receptor (ER) status (p=0.001), progesterone receptor (PR) status (p=0.001), HER2 status (p=0.001) and Ki67 proliferation index (p=0.001). 28534358

2019